نتایج جستجو برای: von willebrand disease
تعداد نتایج: 1579959 فیلتر نتایج به سال:
von Willebrand factor is a multimeric plasma glycoprotein that is required for normal haemostasis. von Willebrand factor is synthesized by endothelial cells and megakaryocytes, and originates from its precursor pro-von Willebrand factor. The endoproteolytic processing of pro-von Willebrand factor results in mature von Willebrand factor and von Willebrand factor propeptide (also known as von Wil...
Background Von Willebrand ́s disease (VWD) is the most common congenital disorder of hemostasis, characterized by deficient or defective von Willebrand factor. Patients are treated by intravenous replacement of factor VIII/VW (FVIII/ VW) when needed, for prophylaxis before surgical procedures. Anaphylactic reactions to FVIII/VW are rare and desmopressin (DDAVP) can be used as an alternative.
OBJECTIVE To analyze the preoperative plasma antigenic concentration and activity of von Willebrand factor and its main cleaving protease ADAMTS-13 in pediatric patients with cyanotic congenital heart disease undergoing surgical treatment and investigate possible correlations with postoperative bleeding. METHODS Plasma antigenic concentrations (von Willebrand factor:Ag and ADAMTS-13:Ag) were ...
Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands; AB Bonomi Hemophilia and Thrombosis Centre, Foundation IRCCS Ca’ Granda Maggiore Policlinico Hospital and University of Milan, Milan, Italy; Hematology Department, San Bortolo Hospital, Vicenza, Italy; Hämostaseology, Medilys Laborgesellsch...
A modification of Salzman's method has been used in an attempt to provide an assay in vitro for the von Willebrand factor. Platelet adhesiveness was increased in von Willebrand's disease by previously coating the beads with normal or haemophilic plasma or cryoprecipitate, whereas von Willebrand plasma had no corrective effect. Antihaemophilic factor (AHF) concentrates were studied in the same w...
Von Willebrand disease (VWD) is the common autosomal bleeding disorder caused by a quantitative and/ or qualitative defect in the Von Willebrand Factor (VWF), a large multimeric multifunctional plasma glycoprotein which plays a critical role in hemostasis. It is essential for platelet adhesion to damaged endothelium as well as platelet interactions at high shear stress. VWF has a direct role in...
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