PURPOSE To evaluate our hospital protocol of low-dose vitamin K titration for preoperative warfarin reversal for early hip fracture surgery. METHODS Records of 16 men and 33 women aged 63 to 93 (mean, 81) years who were taking warfarin for atrial fibrillation (n=40), venous thromboembolism (n=9), cerebrovascular accident (n=3), and prosthetic heart valve (n=3) and underwent surgery for hip fr...

ABSTRACT
 Objective: Ischemic complications or massive bleeding are important perioperative in elderly patients using antithrombotic drugs. The need for blood product replacement, transfusion-related complications, prolonged stay hospital and intensive care unit, high mortality the period can be seen. aim of this study was to investigate effects long-term different therapies on morbidity u...

Traditional anticoagulants, such as warfarin and enoxaparin, have several limitations, including parenteral administration, need for laboratory monitoring, and ongoing dose adjustment, which may limit optimal patient care. Newer oral anticoagulants, such as direct thrombin inhibitors (e.g., dabigatran etexilate) and direct factor Xa inhibitors (e.g., rivaroxaban, apixaban, and edoxaban), have b...

BACKGROUND Apixaban, an oral factor Xa inhibitor administered in fixed doses, may simplify the treatment of venous thromboembolism. METHODS In this randomized, double-blind study, we compared apixaban (at a dose of 10 mg twice daily for 7 days, followed by 5 mg twice daily for 6 months) with conventional therapy (subcutaneous enoxaparin, followed by warfarin) in 5395 patients with acute venou...

As the population ages and medical care, along with a functional life style, continues to improve the health of this group, the number of joint replacement surgeries will continue to rise each year in the United States. This growing volume carries with it the risk of venous thromboembolism associated with joint replacement surgery. The American College of Chest Physicians and the American Acade...

BACKGROUND After arthroplasty treatment, some complications commonly occur, such as early revision, infection/dislocation, and venous thromboembolism (VTE). This study aims to use a network meta-analysis to compare effects of 9 anticoagulant drugs (edoxaban, dabigatan, apixaban, rivaroxaban, warfarin, heparin, bemiparin, ximelagatran, and enoxaparin) in preventing postoperative complications in...

The efficacy of novel oral anticoagulants (NOACs) in preventing deep venous thrombosis (DVT) has been established in large multicenter trials. Predictable pharmacokinetics, avoidance of routine laboratory monitoring, and lesser drug interactions have made NOACs safer and more tolerable treatment option in comparison to warfarin. However, cases of treatment failure mainly due to interindividual ...

Laboratory studies and animal models have suggested that the activation of the clotting cascade may be important in the pathogenesis of idiopathic pulmonary fibrosis (IPF) [1–3]. Epidemiological studies have also suggested a strong association between IPF and venous thromboembolism (VTE) [4–6]. We estimated the incidence of pulmonary embolus and deep vein thrombosis (DVT) in people with IPF and...

Right atrial thrombus formation is a known mechanical complication of central venous catheter insertion, with an incidence of between 1.9% and 42%. There is an increased risk of thromboembolism following renal transplantation. However, a right atrial thrombosis is rarely reported in renal transplant recipients. Here, we report two cases of renal transplant recipients in whom a right atrial thro...

Unprovoked venous thromboembolism (VTE) warrants anticoagulant therapy for a brief period of weeks to months. After it is discontinued, the risk of recurrent VTE remains high. Long-term warfarin therapy is highly effective in preventing recurrence, but it has an increased risk of bleeding, and the monitoring requirements make it inconvenient and costly for patients. Low-dose aspirin is a propos...