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not have been systematically collected or reported, raising issues of ascertainment bias. This issue is even more challenging because all patients had cognitive impairment. Second, study discontinuation rates were high and there was not a planned, rigorously conducted period of off-drug follow-up. In addition, our analysis updates the published findings from study 078, since a subsequent invest...
Epidemiological and genetic variables in hypospadias were analysed during the years 1978 to 1983 in a case control study of congenital malformations in the Emilia Romagna region of northern Italy. During the observation period, in a sample of 41 078 male newborns, 168 had hypospadias giving a prevalence at birth of 4.1 in 1000 males. Hypospadias was divided into three types: type I or mild (75....
Abstract Study question Following quantitative NGS for PGT-A, do current thresholds mosaicism calling give a true reflection of the presumed mitotic origin mosaic errors? Summary answer A large proportion embryo diagnosed following NGS-based PGT-A does not correlate with and expected origin, showing instead meiotic signatures. What is known already Mosaicism biological phenomenon that can affec...
Geriatric medicine has an encyclopaedic sweep, reflecting the complexity of both the ageing process and of our patient group. Keeping up with, and making sense of, the relevant scientific literature is challenging, especially as ageing has increased in prominence as a focus of research across many branches of the sciences and the humanities. This review of research published in 2012 in generali...
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