For research libraries, the long-term preservation of digital collections may well be the most important issue in digital libraries. In certain ways, digital materials are incredibly fragile, dependent for their continued utility upon technologies that undergo rapid and continual change. In the world of physical research materials, a great number of valuable research resources have been saved p...

We report a 13 year old boy with fragile X syndrome resulting from a de novo deletion of the FMR1 and FMR2 genes extending from (and including) DXS7536 proximally to FMR2 distally. The patient has severe developmental delay, epilepsy, and behavioural difficulties, including autistic features. He has epicanthic folds, in addition to facial features typical of fragile X syndrome, and marked joint...

Inter-and intra-agency coordination-The accountability, will and capacity of donors 25 6.4 A new sector financing strategy in education-transitional trust funds .. 1.1 Structure of the Paper The DAC characterises fragile states as countries with poor governance as identified by a lack of political commitment and/or weak capacity to develop and implement pro-poor policies; fragile states also of...

autism and fragile x syndrome have multiple behavioral phenotypes in common, however there has been little research into the potential role of fragile x mental retardation protein (fmrp) in autism. we sought to measure protein levels of fmrp in the lateral cerebella of subjects with autism and matched controls. we found significantly reduced levels of fmrp (p<0.0063) in subjects with autism. th...

Dendritic spine abnormalities and the metabotropic glutamate receptor theory put the focus squarely on synapses and protein synthesis as the cellular locus of fragile X syndrome. Synapses however, are only partly responsible for information processing in neuronal networks. Neurotransmitter triggered excitatory postsynaptic potentials (EPSPs) are shaped and integrated by dendritic voltage-gated ...

The materials, painting techniques and conservation state of the enamelled stain glass Catalan Modernist workshops operating in Barcelona are studied. It is known for its creativity artistic value where textured, flashed, coloured glasses concur. In late 19th century, used a new type ready-to-be-used enamels (lead-zinc borosilicate glass) incorporating pigment particles colourants. Although hum...

Two classes of digital watermarks have been developed to protect the copyright ownership of digital images. Robust watermarks are designed to withstand attacks on an image (such as compression or scaling), while fragile watermarks are designed to detect minute changes in an image. Fragile marks can also identify where an image has been altered. This paper compares two fragile watermarks. The fi...

Authentication watermarking approaches can be classified into two kinds: fragile and semi-fragile. In contrast to the latter one, fragile watermarking does not tolerate modifications of any single bit of the watermarked data. Since the transmission of digital data often requires lossy compression, an authentication system should accept non-malicious modifications such as JPEG compression. Semi-...

The formation of alternative DNA secondary structures can result in DNA breakage leading to cancer and other diseases. Chromosomal fragile sites, which are regions of the genome that exhibit chromosomal breakage under conditions of mild replication stress, are predicted to form stable DNA secondary structures. DNA breakage at fragile sites is associated with regions that are deleted, amplified ...