Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. An important stressor associated with affective disorders is the experience of childhood emotional maltreatment (CEM). We investigated whether the interaction of NPY risk genotype and CEM would affect brain activation. From The Netherlands Study of Depression and...

BACKGROUND Both anxiety and elevated heart rate (HR) have been implicated in the development of hypertension. The HyperGen cohort, consisting of siblings with severe and mild hypertension, an age-matched random sample of persons from the same base populations, and unmedicated adult offspring of the hypertensive siblings (N = 1,002 men and 987 women), was analyzed for an association of the angio...

The insertion/deletion polymorphism of the angiotensin I– converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers. Using genomic DNA from 88 patients with early gastric cancer confined either to mucosa (pT1a) or submucosa (pT1b), we assessed the insertion (I) and deletion (D) polymorphism by PCR analysis and compared it with a large noncancer c...

We report on diffuse X-ray emission associated with the nearby solitary millisecond pulsar PSR J2124−3358 detected with XMM-Newton and Chandra. The emission extends from the pulsar to the northwest by ∼ 0.5 arcmin. The spectrum of the nebular emission can be modeled with a power-law of photon index 2.2 ± 0.4, in line with the emission originating from accelerated particles in the post shock flo...

Low energy X-ray emission (0.1-10 keV) from all six millisecond radio pulsars (MSPs) for which such emission has been reported support a proposed pulsar magnetic field evolution previously compared only to radiopulse data: old, very strongly spun-up neutron stars become mainly orthogonal rotators (magnetic dipole moment perpendicular to stellar spin) or aligned rotators. The neutron star proper...

Properties of X-ray radiation emitted from the polar caps of a radio pulsar depend not only on the cap temperature, size, and position, but also on the surface chemical composition, magnetic field, and neutron star's mass and radius. Fitting the spectra and the light curves with neutron star atmosphere models enables one to infer these parameters. As an example, we present here results obtained...

The insertion/deletion polymorphism of the angiotensin I-converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers. Using genomic DNA from 88 patients with early gastric cancer confined either to mucosa (pT(1a)) or submucosa (pT(1b)), we assessed the insertion (I) and deletion (D) polymorphism by PCR analysis and compared it with a large noncance...

We demonstrate that the sensitivity of high-precision pulsar timing experiments will be ultimately limited by the broadband intensity modulation that is intrinsic to the pulsar’s stochastic radio signal. That is, as the peak flux of the pulsar approaches that of the system equivalent flux density, neither greater antenna gain nor increased instrumental bandwidth will improve timing precision. T...

OBJECTIVE Many studies suggest an association between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and anxiety-related personality traits (e.g., neuroticism) in healthy subjects. This study investigated the interaction of 5-HTTLPR genotype on body dissatisfaction by neuroticism and to evaluate the interaction of 5-HTTLPR genotype on self-esteem by body dissatisfaction in ...