is in the vicinity of 5,000 blood donations annually, apart from the cost of the associated equipment for the preparation of platelet concentrates and the salary of a technologist over and above the salaries of the blood collection staff necessary. In this country we have available a "mini-exchange" set,3 comprising a needle and tubing connected to one limb of a Ypiece which has a free length o...

Sepsis of the newborn induced by gram negative bacteria, especially E. coli is often accompanied by a severe coagulation disorder. It can be treated by blood exchange transfusion (ET) with heparinized blood. In this study the hematological effect obtained by the exchange transfusion was investigated in rabbits after induction of a generalized Shwartzman reaction by two spaced injections of endo...

Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of IgG antibodies in maternal circulatio...

BACKGROUND The use of white cell (WBC)-reduced blood in elective colorectal surgery appears to reduce the frequency of postoperative infection. The question to be addressed is whether the cost:benefit ratio justifies the recommendation that WBC-reduced blood should be used for all colorectal surgery. STUDY DESIGN AND METHODS Patients admitted for elective colorectal surgery (n = 197) were ran...

This article reports the details of delayed hemolytic transfusion reactions in four patients with sickle cell disease. These cases demonstrate the characteristics of the reactions, the significant risks involved, and the principles useful in diagnosis and treatment. Patients with sickle cell disease are at particular risk for delayed hemolytic transfusion reactions because they may be transfuse...

The relation between maternal anti-D concentrations, measured against the British working standard, and outcome of rhesus-sensitised pregnancies was studied. There is a clear relation between increasing anti-D concentrations and the chance of a severely affected baby. Of those pregnancies (78) where serial anti-D concentrations remained below 4 IU/ml, no baby had a cord haemoglobin below 10 g/d...

There can be little doubt that at the present stage of our knowledge exchange transfusion is the best method of treating haemolytic disease of the newborn, at least in moderate and severe cases. Recently this viewpoint has been conclusively confirmed by widely based and controlled trials of British workers (Mollison and Walker, 1952; Armitage and Mollison, 1953); their results showed that the m...

Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group. Serum bilirubin levels of the treated infants from day 4 onwards were consistently lower than those of the control infants. 3 of the 25 control infants (but none of the 25 treated infants) had bilirubin levels greater than 18 mg/100 ml (308 mumol/l) and required exchange...

BACKGROUND AND OBJECTIVE Several studies have shown the benefits of delayed cord clamping (DCC) in preterm and in healthy newborns at short and long term. Our objective was to evaluate the potentials benefits and risks of DCC in red cell alloimmunization. METHODS This was a comparative before/after study of all living born neonates followed after fetal anemia requiring in utero transfusion. D...

Automated method for exchange transfusion Sir, In their report (Archives, 1972, 47, 815) M. G. Philpott and A. Banerjee presented a technique of exchange transfusion based on the use of a Holter infusion pump with two channels connected to umbilical vein and artery. In 1971 we (Garofalo, Minerva, and Baltieri, 1971) described a method of exchange transfusion by means of Holter microinfusion rol...