The WTX gene is frequently lost or mutated in Wilms tumor. In this issue of Molecular Cell, Kim et al. (2012) identify WTX modulation of p53 tumor-suppressor activity through regulation of p53 acetylation. Therefore, WTX differentially regulates the oncogenic β-catenin pathway and the tumor-suppressing p53 pathway.

IntroductIon Nephrogenic rests (NRs) are abnormally persistent clusters of embryonal cells, representing microscopic dysplasias of the developing kidney. NRs are found in approximately 1% of infant kidneys at autopsy. Nephroblastomatosis signifies the presence of multiple or diffuse NRs. Both NRs and nephroblastomatosis were known as precursor lesions of Wilms’ tumor.[1] Nephroblastomatosis can...

Innervation of deep endometriosis has recently been linked to its severe pain symptoms. We demonstrated for the first time that the Wilms' tumor gene 1 is overexpressed in part of these nerves.

Wilms tumor is the most common childhood renal tumor accounting for about 6% of pediatric malignant disease. Most patients with Wilms tumor can be cured with treatment and subsequently lead normal life. The multidisciplinary management of Wilms tumor has resulted striking improvement in survival of more than 85% nowadays and has become a paradigm for successful cancer therapy. We describe the r...

WAGR syndrome is an acronym for a rare constellation of congenital abnormalities including predisposition to Wilms' tumor, Aniridia, Geni tourinary malformations, and mental Retardation. These congenital de fects are associated with a constitutional deletion affecting one copy of chromosome band Ilpl3, implicating the loss of one alÃ-elefrom a number of contiguous genes in this syndrome. Predis...

Abstract The Wilms' tumor 1 (WT1) gene is well known as a chameleon gene. It plays role suppressor in but also acts an oncogene other cancers. Previously, our group reported that canonical AUG starting site for the WT1 protein (augWT1) suppressor, whereas CUG (cugWT1) functions oncogene. In this study, we report oncogenic of cugWT1 AOM/DSS-induced colon cancer mouse model and urethane-induced l...

We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor based primarily on radiologic findings. Neoadjuvant chemotherapy consisting of vincristine, dacti...