Intrinsically disordered proteins (IDPs) form a unique protein category characterized by the absence of a well-defined structure and by remarkable conformational flexibility. Electron Paramagnetic Resonance (EPR) spectroscopy combined with site-directed spin labeling (SDSL) is amongst the most suitable methods to unravel their structure and dynamics. This review summarizes the tremendous method...

Evolutionary Polynomial Regression (EPR) is a recently developed hybrid regression method that combines the best features of conventional numerical regression techniques with the genetic programming/symbolic regression technique. The original version of EPR works with formulae based on true or pseudo-polynomial expressions using a single-objective genetic algorithm. Therefore, to obtain a set o...

INTRODUCTION EPR imaging using nitroxides is a powerful non-invasive method for visualizing the redox status modulated by oxidative stress in vivo. Recently we successfully reduced the scan time of three-dimensional (3D) EPR imaging of nitroxides in rodents. This system enables us to obtain 3D images of nitroxide probes with a half-life of a few minutes in living mice [1]. Another advantage of ...

Since the first report of the enhanced permeability and retention (EPR) effect, the research in nanocarrier based antitumor drugs has been intense. The field has been devoted to treatment of cancer by exploiting EPR-based accumulation of nanocarriers in solid tumors, which for many years was considered to be a ubiquitous phenomenon. However, the understanding of differences in the EPR-effect be...

The optical spectrum band positions and EPR parameters (g factors g//, g⊥ and hyperfine structure constants A// and A⊥) for VO 2+ ions in zinc potassium phosphate hexahydrate are theoretically studied from the complete diagonalization (of energy matrix) method (CDM). In the calculation, the contributions to the EPR parameters from the s-and p-orbitals as well as the spin-orbit coupling coeffici...

A new method for tooth (enamel and dentine) and bone EPR dosimetry is proposed that enhances substantially the dosimetric sensitivity. The method is based on the nonstandard spectra registration mode (the second harmonic phase quadrature detection of absorption under rapid passage conditions). This method provides an apparent enhancement of the component ratio of radiation to a nonradiative bac...

BACKGROUND Electronic patient records (EPRs) are increasingly being used in health care, but little is known about how EPR-based patient information is used in daily care activities, nor about its potential influence on novice training. METHOD Seventy-two physicians and nurses participated in an eight-month study on a single pediatric ward. Eighty hours of nonparticipant observations and 20 i...

Lightning protection system (LPS) for wind power generation has become an important public issue due to greatly increasing installations of wind turbines (WTs) worldwide. Grounding system is one of the most important components required for appropriate LPS for WTs. Although the finite-difference time-domain (FDTD) method for solving Maxwell`s equations is difficult for computing earth potential...

Electron paramagnetic resonance (EPR) spectroscopy was used for examination of free radicals in thermally treated vaselinum album (VA). Thermal treatment in hot air as sterilization process was tested. Conditions of thermal sterilization were chosen according to the pharmaceutical norms. Vaselinum album was heated at the following conditions (T--temperature, t--time): T = 160°C and t = 120 min,...

The reaction of CH3O2 radicals with acetaldehyde on the solid surface of NH4NO3 has been studied in a flow capillary reactor at low pressure and room temperature. The experiments were performed using EPR spectrometer combined with the kinetic method of radicals freezing. Peroxy radicals revealed an oscillation complex behavior during the process regarding to the phenomenon of radicals multiplic...