withania somnifera (l.) dunal is an erect evergreen shrub commonly known as ashwagandha. it is widely used in ayurvedic, and in the traditional pharmacopeia system of india. it is one of the major ingredients in many formulations prescribed for a variety of musculo-skeletal conditions including arthritis and rheumatism. in the present study, variations in the quality and quantity of proteins an...

A total of two new (1, 2) and four known (3-6) withanolides were isolated from the whole plant of Withania somnifera. Their structures were elucidated on the basis of spectroscopic techniques and were characterized as 6alpha,7alpha-epoxy-3beta,5alpha,20beta-trihydroxy-1-oxowitha-24-enolide (1), 5beta,6beta-epoxy-4beta,17alpha,27-trihydroxy-1-oxowitha-2,24-dienolide (2), withaferin-A (3), 2,3-di...

The present experiment was aimed to assess imidacloprid induced alterations in oestrous cycle and ameliorative effects of Withania somnifera rats. 48 female albino Wistar rats were divided into four groups 12 animals each. Group 1 is control, group 2 (30 mg/kg body weight/d), 3 (1 g/kg feed) 4 imidacloprid+Withania weight/ d+1 feed). test chemical administered daily by oral gavage for 30 d. Sev...

Neutralization effects of Acorus calamus and Withania somnifera root extracts were tested against Echis carinatus venom. Both plant extracts were effectively neutralized the various pharmacological activities induced by Echis carinatus venom. About 0.14 mg of Acorus calamus and 0.16 mg of Withania somnifera root extracts were able to completely neutralize the lethal a...

OBJECTIVE The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha, WS) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity. DESIGN This review is in a narrative format and consists of all publications relevant to ashwagandha that were i...