background: this study was designed to investigate the efficacy of pentoxifylline (ptx) in the treatment of irradiated wounds. materials and methods: ten female pigs of the large white strain were used in these investigations. six skin fields, 4 * 4 cm and separated from each other by 4 cm, were marked out on each flank and those on left flank were irradiated with 18gy single dose of 250 kv x-r...

BACKGROUND Cathepsin S is a cysteine protease, which is expressed in human periodontal ligament (PDL) cells under inflammatory and infectious conditions. This in vitro study was established to investigate the effect of cathepsin S on PDL cell wound closure. METHODS An in vitro wound healing assay was used to monitor wound closure in wounded PDL cell monolayers for 72 h in the presence and abs...

In the present investigation, methanolic extract of Mimusops elengi  leaves were evaluated for wound healing activity. Entire wound healing process is complex series of events that begins at the moment of injury and can continue for months to years. Methanolic extract of Mimusops elengi leaves were examined for wound healing activity in the form of ointment by the excision, the incision and ...

BACKGROUND Birch bark has a long lasting history as a traditional medicinal remedy to accelerate wound healing. Recently, the efficacy of birch bark preparations has also been proven clinically. As active principle pentacyclic triterpenes are generally accepted. Here, we report a comprehensive study on the underlying molecular mechanisms of the wound healing properties of a well-defined birch b...

the effect of prepared ayurvedic formulation was evaluated on excision and incision wound models in rats. the wound-healing activity was assessed by the rate of period of epithelialization and skin-breaking strength. histological study of the granulation tissue was carried out to know the extent of collagen formation in the wound tissue. the ayurvedic formulation prepared was then promoted for ...

The purpose of this study was to investigate the wound healing effect of acai berry water extracts (ABWE) and a possible underlying mechanism involved in its action using various in vitro and in vivo models. The wound healing effect of ABWE was evaluated by migration assay using HS68 fibroblast cells. In addition, its effect on mRNA expression of procollagen, fibronectin, and MMP-1 was determin...

Introduction: Several factors such as diseases, medications and humoral agents can delay or speed up wound healing process. Because of the limited information about the hormonal changes during wound healing, in this study the relationship between serum levels of growth hormone, insulin and cortisol and wound healing in normal and diabetic rats was evaluated. Methods: Male Wistar rats )weigh...

objectives: wound is defined simply as the disruption of the biochemical, cellular, and anatomic continuity of a tissue. plants and their extracts known as phytomedicine have immense potential for the management and treatment of wounds. materials and methods: due to the undesirable side effects, in the control and treatment of the wound infections, it is recommended to use natural materials suc...

the present study was conducted to investigate the histological changes and wound healing effect of aqueous extract of elaeagnus angustifolia. after creating full-thickness skin wounds on the back of 45 male sprague-dawley rats they were randomly divided into three groups. treated group received the extract, positive control group were treated with mupirocin ointment 2% and control group did no...

the microorganisms have been noted as the main cause of delayed wound healing.the most common pathogen causing the wound infections is staphylococcus aureus. silver nanoparticles (agnps) show ample antibacterial activities. in the present study, the effect of agnps on mouse wounds inoculated with s. aureus was investigated. sixty male mice (20 to 30 g) were anesthetized, full-thickness skin wou...