The widespread occurrence of antibodies (IgG) specific to xanthine oxidase in both normal (nonimmune) human and animal sera, and in antisera raised against a diversity of unrelated antigens is described. A study of sera from 81 humans revealed that xanthine oxidase-specific IgG represents a high proportion (1-8%) of total IgG. No obvious correlation to pathological events or symptoms of disease...

To achieve potential alternatives for hyperuricemia therapeutics, a novel structure-docking energy relationship model was established high-throughput screening inhibitors of xanthine oxidase (XO). Molecular docking performed between XO and 311 natural compounds from 6 traditional Chinese herbs. Then, simulated molecular 63 descriptors by multiple linear regressions (MLR), principal component re...

Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides exhibited strong inhibitory activities against xanthine oxidase in vitro. Their half-maximal inhi...

We have recently reported’ the inhibition of xanthopterin oxidase and xanthine oxidase by synthetic pteroylglutamic acid (PGA). However, since an exceptionally pure sample2 of PGA, which was later examined, possessed less than one-sixth of the inhibitory power previously observed, it appears possible that the effect is due to traces of a contaminant. The observation by Lowry and Bessey3 that 2-...

BACKGROUND α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that catalyzes hypoxanthine and xanthine to uric acid which at high levels can lead to hyperuricemia which is an important cause of gout. Pancreatic lipase (PL) secreted into the duodenum ...

Picea koraiensis Nakai (PK) is an evergreen tree. It plays important role in landscaping and road greening. Insect galls of PK are formed by parasitism the adelgid Adelges laricis. Except for phenolics, other chemical constituents biological activity insect gall from still unknown. Thus, here, we performed phytochemical analyses extracts, aiming to turn waste into treasure serve human health. e...

A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin has a significant inhibitory effect on xanthine oxidase in vitro, and the IC50 was 11.16 nmol/mL.

A low protein diet (1, 2) removed about three-fourths of the xanthine oxidase from the entire rat (3), while a purified diet containing tungstate reduced the tissue xanthine oxidase to a level at which it could not, be detected manometrically (4) ; neither of these dietary procedures had any effect on the uric acid or allantoin excretion by this species. Chicks fed a tungstate-containing diet e...

In a previous study (1) it was shown that dogs maintained on a purified diet developed a defect in acetaldehyde metabolism. Of the five known enzyme systems that could theoretically be involved in acetaldehyde metabolism in viva (aldolase, mutase, carboxylase, aldehyde ox&se, and xanthine oxidase), the xanthine and aldehyde oxidases seemed most likely to be dependent upon a dietary factor not a...

Among 288 extracts, prepared from 96 medicinal plants used in Vietnamese traditional medicine to treat gout and related symptoms, 188 demonstrated xanthine oxidase (XO) inhibitory activity at 100 microg/ml, with 46 having greater than 50% inhibition. At 50 microg/ml, 168 of the extracts were active, with 21 possessing more than 50% inhibition. At 25 microg/ml, 146 extracts exhibited inhibitory ...