Fifty-year-old female without a known disease was admitted with weakness and fatigue. In family history, her sister had a myocardial infarction when she was 55 years old and hypertriglyceridemia, her father and mother have hypertension but don’t have dyslipidemia. On physical examination body weight 76 kg, height 165 cm, body mass index 27.9 kg/m2, abdominal circumference 92 cm, xanthomas were ...

We report a case of diffuse plane xanthoma in a 40-year-old otherwise healthy woman. Her disease began 18 years ago as xanthelasma and progressed to involve large areas of her face, neck and trunk. No associated diseases were detected on repeated laboratory testing.

Xanthoma disseminatum (XD) is a rare normolipemic histiocytic disorder of non-Langerhans cell origin characterized by erythematous to tan/brown papules in flexor surfaces. Considered a generally benign, chronic disease of unknown etiology, XD typically affects the skin, mucous membranes, and less commonly, other organs. To date, there has been no typical or consistent inheritance pattern descri...