BACKGROUND The goal of this study was to investigate the effects of pulmonary static inflation with 50% xenon on postoperative oxygen impairment during cardiopulmonary bypass (CPB) for Stanford type A acute aortic dissection (AAD). METHODS This prospective single-center nonrandomized controlled clinical trial included 100 adult patients undergoing surgery for Stanford type A AAD at an academi...

Xenon-133 was used to study regional pulmonary function in nine patients with chest cage rigidity due to ankylosing spondylitis. In comparison with normal subjects, the patients showed an overall diminution in lung volume and the proportion of inhaled xenon reaching the lung apices was reduced but the distribution of injected xenon was normal. The possible relationship between these findings an...

Recently we found that (pentafluorophenyl)xenon(II) hexafluoroarsenate [CöF5Xe]+ [AsFö]reacted easily with xenon difluoride and FLO in HF to yield (pentafluoro-l,4-cyclohexadien-3-onl-yl)xenon(II) hexafluoroarsenate [1], In order to prove the scope of the synthetic use of this new powerful oxygenating reagent, the interaction with pentafluorobenzene derivatives C6F5X containing electron-donor a...

971 May 2015 F OR chemists and physicists, xenon is a noble gas with 54 protons and low reactivity (or “inert”) due to an outer shell that is replete with electrons. For anesthesiologists, xenon is a drug with remarkable properties as a fast-acting anesthetic, analgesic, cardioprotectant, and neuroprotectant.1,2 But how does it work? In this issue of AnesthesIOlOgy, Mattusch et al.3 report an i...

BACKGROUND While volatile agents have been implicated in metastasis-enhancing effects on cancer cells, the effects of xenon are unknown. We investigated xenon- and sevoflurane-mediated effects on migration and expression of angiogenesis biomarkers in human breast adenocarcinoma cells. METHODS MDA-MB-231 and MCF-7 cells were exposed to xenon 70% with O2 25%, CO2 5%; control gas containing O2 2...

Postoperative cognitive decline (POCD) is a common complication following surgery, but its aetiology remains unclear. We hypothesized that xenon pretreatment prevents POCD by suppressing the systemic inflammatory response or through an associated protective signaling pathway involving heat shock protein 72 (Hsp72) and PI3-kinase. Twenty-four hours after establishing long-term memory using fear ...

In recent years, quantitative determination of cerebral blood flow (CBF) by xenon-enhanced CT has become an increasingly important research and clinical tool. Concurrently, the possibility that inhalation of stable xenon in the concentrations required for this procedure might itself alter CBF also has received increasing attention. Several studies [1-6] have examined this problem by using vario...

Results. Propofol supplementation was necessary in six xenon patients (29%) because of detectable movement of the upper body. Emergence time was significantly shorter with xenon (260 s for xenon and 590 s for propofol, P=0.001). There was no significant difference between the groups in blood pressure, heart rate, ventilatory frequency or end-tidal carbon dioxide concentration. No difference cou...

BACKGROUND Xenon has minimal haemodynamic side effects when compared to volatile or intravenous anaesthetics. Moreover, in in vitro and in animal experiments, xenon has been demonstrated to convey cardio- and neuroprotective effects. Neuroprotection could be advantageous in paediatric anaesthesia as there is growing concern, based on both laboratory studies and retrospective human clinical stud...

BACKGROUND There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous anaesthesia with propofol. METHODS A total of 160 patients aged 18-60 years (ASA I and II) undergoing elective surgery took part in this prospective non-blinded randomized controlled trial. After loca...