Given a non-degenerate quadratic form over a field such that its maximal orthogonal grassmannian is 2-incompressible (a condition satisfied for generic quadratic forms of arbitrary dimension), we apply the theory of upper motives to show that all other orthogonal grassmannians of this quadratic form are 2-incompressible. This computes the canonical 2-dimension of any projective homogeneous vari...

In Part I it was shown that if G is a p-group of class k, generated by elements of orders 1 < p1 ≤ · · · ≤ pr , then a necessary condition for the capability of G is that r > 1 and αr ≤ αr−1 + ⌊ k−1 p−1 ⌋. It was also shown that when G is the k-nilpotent product of the cyclic groups generated by those elements and k = p = 2 or k < p, then the given conditions are also sufficient. We make a corr...

FocalinTM XR (dexmethylphenidate hydrochloride) extended-release capsules is an extended-release formulation of dexmethylphenidate with a bi-modal release profile. FocalinXR uses the proprietary SODASTM (Spheroidal Oral Drug Absorption System) technology. Each bead-filled Focalin XR capsule contains half the dose as immediate-release beads and half as enteric-coated, delayed-release beads, thus...

Extreme Requirements (XR) is a proposal that tries to improve the quality of Extreme Programming (XP). XP is a well known agile method for software production. XP key elements are: little documentation, simplicity, analysis as constant activity, evolutionary design, integration and daily test. XR defines a requirements strategy that can be coupled with XP. In this article, we present an XR busi...

AIMS To determine prospectively the efficacy, tolerability and patient satisfaction of an extended release formulation of metformin (metformin XR) in hospital based outpatients with type 2 diabetes mellitus currently treated with standard metformin. METHODS Patients on immediate release standard metformin either alone or combined with other oral agents were switched to extended release metfor...

OBJECTIVE Evaluate safety and efficacy of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS 10-week interim analysis of the Quality of life, Effectiveness, Safety, and Tolerability (QU.E.S.T.) trial, an ongoing, 30-week, open-label, multicenter investigation of once-daily MAS XR (10-60 mg/day) in adults (>or=18 years of a...

"Forgiveness" - the difference between a drug's postdose duration of action and its prescribed dosing interval - estimates the margin of therapeutic effect following a missed dose. Because this margin presumably decreases as dosing becomes less frequent, QD dosing of an antiepileptic drug (AED) is expected to be less forgiving than more frequent (e.g., BID) dosing of that same AED. However, if ...

s away from the specialization benefit that is surely an important reason for delegated decision making. We also assume that the voter is capable of determining which of the policy options is in his best interest. A natural starting point to address the issues of expertise and voter ignorance would be to include policy uncertainty along the lines of Gilligan and Krehbiel (1987). This would pres...

OBJECTIVE This study examined the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). METHOD This 8-week, placebo-controlled, fixed-dose trial, including 3 weeks of dose escalation, of patients 6 to 17 years old with ADHD evaluated the efficacy and safety of CLON-XR 0.2 mg/day or CL...