OBJECTIVE To evaluate the cost-effectiveness of a new extended-release (XL) formulation of oxybutynin relative to tolterodine immediate release (IR), currently the most prescribed treatment for overactive bladder in the UK. METHODS A state-transition model was developed to compare outcomes over 1 year. Effectiveness and treatment persistence data were derived from the OBJECT (Overactive Bladd...

Following the publication of major trials and other studies of hormone replacement therapy, patients in the UK have been advised not to take the drug long-term and to limit short-term use. Response to the new evidence in terms of prescribing in the US has been published recently and we thought it important to assess changes in use in England. Prevalence of use in England increased steadily in t...

The European Seascape of the Restricted Area (ERA) and decision Council Europe Union (2002/584 / TAC) from 13 June 2002, was published in Official Gazette Community for 18 July 2002. arrest warrant is charge before moment convention extradition, (без attach) between formal nationality Extradition procedure procedure) betrayal among EU Member States based on warrant. problem principle reciprocal...

This paper reports the effects of a comprehensive elementary school-based social-emotional and character education program on school-level achievement, absenteeism, and disciplinary outcomes utilizing a matched-pair, cluster randomized, controlled design. The Positive Action Hawai'i trial included 20 racially/ethnically diverse schools (mean enrollment = 544) and was conducted from the 2002-03 ...

OBJECTIVES To investigate the effectiveness of telephone counselling as an adjunct to nicotine replacement therapy (NRT) by transdermal patch in smoking cessation. DESIGN Randomised controlled trial. PARTICIPANTS AND SETTING 854 smokers from New South Wales, aged 18 years and older, who had smoked at least 10 cigarettes per day for the past year and responded to newspaper advertisements bet...

This study is a 2-year follow-up of girls with serious and chronic delinquency who were enrolled in a randomized clinical trial conducted from 1997 to 2002 comparing multidimensional treatment foster care (MTFC) and group care (N = 81). Girls were referred by juvenile court judges and had an average of over 11 criminal referrals when they entered the study. A latent variable analysis of covaria...

Introduction No effective treatment has been developed for bone-metastatic breast cancer. We found 3 cases with clinical complete response (cCR) of the bone metastasis and longer overall survival of the retrospectively examined cohort treated comprehensively including autologous formalin-fixed tumor vaccine (AFTV). Patients and Methods AFTV was prepared individually for each patient from thei...