Primary cardiac tumour is a rare entity as secondaries in the heart are more common. A 2-year-old child was having repeated respiratory tract infection with poor oral intake and poor activity for 3 months. His symptoms progressed from New York Heart Association (NYHA) Class II to IV. On evaluation he had an intracardiac mass with extracardiac extension. Emergency tumour excision under deep hypo...

Extraovarian yolk sac tumor (YST) is an extremely rare malignancy occurring mainly in girls and young women of childbearing ages and commonly treated with fertility-sparing surgery and postoperative adjuvant chemotherapy. We report a case treated with neoadjuvant chemotherapy (NACT) followed by cytoredutive surgery and adjuvant chemotherapy. A 32-year-old single woman came for a second opinion ...

Hematopoiesis is the developmentally regulated and tissue-specific process of blood cell production. The predominant anatomic site of hematopoiesis changes several times during murine and human ontogeny. Blood and endothelial cells become morphologically identifiable on embryonic day 7.5 (E7.5) in the developing murine yolk sac blood islands.1 Upon initiation of blood flow through the systemic ...

Background: To evaluate the role of 3D, 4D and color Doppler ultrasound (US) in the assessment of early human development. Materials and Methods: 380 women with uncomplicated early pregnancy between 5 and 14 weeks were evaluated by 3D, 4D and color Doppler US. Results: Regression analysis revealed exponential rise of the gestational sac volume with gestational age throughout the first trimester...

To reveal differentiation potency of yolk-sac endoderm, this tissue from quail embryos was cultured alone or in association with digestive-tract mesenchymes of chick embryos. When yolk-sac endoderm was cultured alone in vitro, the endoderm of the area vitellina differentiated into the yolk-sac parenchyma, but the endoderm of the extraembryonic area pellucida (EEAP) failed to differentiate into ...

Our goals were to determine the prognostic value of a yolk sac or fetal heart motion seen during an early accurately dated transvaginal ultrasound (TVU). We reviewed 225 consecutive pregnancies for fetal heart motion data. Furthermore, 63 pregnancies following in-vitro fertilization were reviewed for yolk sac information. The TVU was performed between 5 and 6 weeks following presumed conception...

Macrophages populate most tissues of the body. They perform many important functions that are required to maintain tissue homeostasis and fight infection, including the uptake and degradation of dead cells, debris, and foreign invaders. Macrophage ontogeny has been debated since the late 1960s when van Furth and Cohn postulated that macrophages are derived exclusively from bone marrow monocytes...

In the adult, platelets are derived from unipotential megakaryocyte colony-forming cells (Meg-CFCs) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs). To better define the developmental origin of the megakaryocyte lineage, several aspects of megakaryopoiesis, including progenitors, maturing megakaryocytes, and circulating platelets, were examined in the murine embryo. We fo...

BACKGROUND Malignant germ cell tumours are the most common malignant tumours in young men. They are histologically divided into seminomas and non-seminomas. Non-seminomas are further subdivided into embryonic carcinomas, yolk sac tumours, chorionic carcinomas, and teratomas. For the therapeutic management it is essential to differentiate between these histological subtypes. METHODS Investigat...