The coordination chemistry of butane-2,3-dione bis (2′-pyridylhydrazone) towards the divalent first-row transition metals zinc and iron has been explored. Depending upon conditions, ligand in six complexes was found to be either neutral, mono, or doubly deprotonated. zinc(II) iron(II) were fully characterized by elemental analysis, mass spectrometry, X-ray diffraction methods.

The three-dimensional structure of (L(-)-2-carboxy-3-phenylpropyl) methylsulfodiimine in its complex with the zinc metalloenzyme carboxypeptidase A has been determined at 2.25-A resolution by x-ray crystallographic methods. This is the first example of a sulfodiimine-containing inhibitor binding to a zinc enzyme, and the structure of the enzyme-inhibitor complex reveals that the tetrahedral sul...

Nanospray and collisionally-induced dissociation are used to evaluate the presence and absence of interstrand co-chelation of zinc ions in dimers of metallothionein. As was reported in a previous publication from this laboratory, co-chelation stabilizes the dimer to collisional activation, and facilitates asymmetrical zinc ion transfers during fragmentation. In the case of metallothionein, dime...

the reaction of copper(ii) chloride and zinc(ii) chloride with n-(2-methylphenyl)-3-(1'-salicylaldehydene-2'-imine-ethane)-butanamide(h2l2a) or (mpsb), n-(2-methylphenyl)-3-(1'-(3'-methoxysalicylaldehydene-2'-imine-ethane)-butanamide (h2l2b) or (mpmsb) and n-(2-methylphenyl)-3-(1'-(2'-hydroxyacetylene-2'-imine-ethane)-butanamide (h2l2c) (mphb) leads to th...

The structure of zinc chloride complexes with different ratios of chloride to zinc, formed in concentrated ZnCl2 aqueous solutions, were determined f rom large-angle X-ray scattering using concentrations of the chloride complexes estimated by complementary Raman spectroscopic measurements. The highest chloro complex, [ZnCl4]~, is tetrahedral with a Zn-Cl bond length of 2.294(4) Ä. The trichloro...

Neurons express adaptor (AP)-3 complexes assembled with either ubiquitous (beta3A) or neuronal-specific (beta3B) beta3 isoforms. However, it is unknown whether these complexes indeed perform distinct functions in neuronal tissue. Here, we explore this hypothesis by using genetically engineered mouse models lacking either beta3A- or beta3B-containing AP-3 complexes. Somatic and neurological phen...

It has been postulated that the development of resistance to known anti-bacterials could be overcome by identifying new drugs. Hence, the objective of the work is to improve upon the existing anti-bacterial activity of the herbal drug molecule. The main purpose is to synthesize and characterize herbo-mineral complexes and evaluate them for antibacterial activity. This research study deals with ...