after iron deficiency, zinc deficiency is the major micronutrient deficiency in developing countries, and staple food fortification is an effective strategy to prevent and improve it among at-risk-populations. no action has been taken to reduce zinc deficiency via flour fortification so far in iran, and little is known about the influence of zinc fortification of flour on serum zinc and the iro...

BACKGROUND Zinc deficiency is commonly prevalent in children in developing countries and plays a role in decreased immunity and increased risk of infection. Preventive zinc supplementation in healthy children can reduce mortality due to common causes like diarrhea, pneumonia and malaria. The main objective was to determine all-cause mortality and cause-specific mortality and morbidity in childr...

For the treatment of cancer, Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic drug target characterized by pathological immune suppression. On the other hand, Withaferin A (WA) – active constituent of Withania somnifera ayurvedic herb has shown to be having a wide range of targeted anti cancer properties. Previously, we have elucidated the potential of WA in attenua...

BACKGROUND The quantified effect of zinc supplementation to prevent childhood diarrhea and respiratory illnesses is unclear. We conducted a meta-analysis of randomized, controlled trials on the subject. METHODS We searched PubMed, Science Citation Index, and the Cochrane Database of Controlled Trials and hand-searched the reference lists of identified articles. All randomized, controlled tria...

Reactions of ZnO nanowires (NWs) with atomic hydrogen were investigated with temperature-programmed desorption (TPD) mass spectrometry, scanning electron microscopy, and photoluminescence (PL) spectroscopy. During TPD, molecular H2, H2O, and atomic Zn desorbed from ZnO NWs pretreated with atomic H at 220 K. Three distinct H2 TPD peaks, two from surface H states and one from a bulk H state, were...

The 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) protein (Gen Bank ID AAN37254.1) from Plasmodium falciparum is a potential drug target. Therefore, it is of interest to screen DXR against a virtual library of compounds (at the ZINC database) for potential binders as possible inhibitors. This exercise helped to choose 10 top ranking molecules with ZINC00200163 [N-(2,2di methoxy ethyl)-6...

The PyAG1 gene, identified by the screening of a Plasmodium yoelii genomic DNA library with a rhoptry-specific Mab, encodes a protein with a zinc finger structure immediately followed by the consensus sequence of the Arf GAP catalytic site. The serum of mice immunized with the recombinant protein recognized specifically the rhoptries of the late infected erythrocytic stages. Blast analysis usin...

desferroxamine (desferal) is used tochelate iron in thalassemia, a disease of very high prevalence in various parts of lran. we have investigated intestinal zinc absorption in desferal-treated rats which, in pilot experiments, showed low serum levels of both iron and zinc. intraperitoneal administration of ten 0.5 g doses of desferal (one injection every other day) to male rats produced severe ...

objective â  febrile convulsion (fc) is a common cause of seizure in young children, withâ an excellent prognosis. in addition to genetic predisposition and infections,fcs are generally thought to be induced by metabolic and elemental changesâ during fever such as zinc (zn) deficiency. regarding the high prevalence ofâ febrile convulsions and the role of zn deficiency, we investigated the role ...