Present paper deals with the synthesis, spectral characterization and X-ray diffraction study of Zn(II) complex with Pioglitazone a new oral antidiabetic drug. The conductometric titration using monovariation method indicate that complex is ionic and L2M type which was further confirmed by Job’s method of continuous variation as modified by Turner and Anderson. Analytical data agree with the mo...

The structures of two zinc complexes containing bidentate benzene-1,2-di-amine ligands are reported. (Benzene-1,2-di-amine-κ(2) N,N')di-chloro-idozinc, [ZnCl2(C6H8N2)], (I), displays a distorted tetra-hedral coordination sphere for the metal cation. The di-amine ligand and the Zn atom reside on a crystallographic mirror plane. In the 1:1 co-crystal salt trans-di-aqua-bis-(4,5-di-methyl-benzene-...

The ability to image the concentration of transition metals in living cells in real time is important for further understanding of transition metal homeostasis and its involvement in diseases. The goal of this study was to develop a genetically encoded FRET-based sensor for copper(I) based on the copper-induced dimerization of two copper binding domains involved in human copper homeostasis, Ato...

A mononuclear complex of Zn(II), [Zn(DIP)(2) (DMP)] (NO(3))(2)·2H(2)O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4'-dimethyl-2,2'-bipyridine has been prepared and characterized by (1)HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the complex were studied using UV-vis spectra, circular dichroism (CD) spectra, fluorescence, cyclic ...

The binding of four inhibitors--mercuric ion, 3-acetoxymercuri-4-aminobenzenesulfonamide (AMS), acetazolamide (Diamox), and thiocyanate ion--to human carbonic anhydrase II (HCA II) has been studied with X-ray crystallography. The binding of mercury to HCA II at pH 7.0 has been investigated at 3.1 A resolution. Mercuric ions are observed at both nitrogens in the His-64 ring. One of these sites i...

objective: thalassemic patients are at risk of zinc deficiency due to various causes including desferal injection, hyperzincuria, high ferritin levels, and hepatic iron overload. we evaluate the effect of zinc supplementation on linear growth of beta-thalassemia patients. methods: one-hundred beta-thalassemic major patients whose heights were within 3rd to l0th percentile were randomly divided ...

Objective: Thalassemic patients are at risk of zinc deficiency due to various causes including desferal injection, hyperzincuria, high ferritin levels, and hepatic iron overload. We evaluate the effect of zinc supplementation on linear growth of beta-thalassemia patients. Methods: one-hundred beta-thalassemic major patients whose heights were within 3rd to l0th percentile were randomly divided ...

The zinc(II) complex with NOTA [2,2',2''-(1,4,7-triazanonane-1,4,7-triyl)triacetate] has previously been synthesized and studied in solution, but was not isolated. The corresponding title Zn(II) complex penta-sodium(I) bis-{[2,2',2''-(1,4,7-triazanonane-1,4,7-triyl)triacetato]zinc(II)} tris-(perchlorate) methanol solvate, Na(5)[Zn(C(12)H(18)N(3)O(6))](2)(ClO(4))(3)·CH(3)OH, was crystallized as ...

The Open University's repository of research publications and other research outputs Metal-directed columnar phase formation in tetrahedral zinc(II) and manganese(II) metallomesogens Journal Article (2008). Metal-directed columnar phase formation in tetrahedral zinc(II) and manganese(II) metallomesogens. Copyright and Moral Rights for the articles on this site are retained by the individual aut...