The vitamin D receptor mediates the signal of 1 alpha, 25-dihydroxyvitamin D3 by binding to vitamin D responsive elements in DNA as a homodimer or as a heterodimer composed of one vitamin D receptor subunit and one retinoid X receptor subunit. We have mapped the dimerization interfaces of the vitamin D receptor that is involved in homo- or heterodimer formation in the absence of DNA. While dele...

Metal-responsive transcription factor-1 (MTF-1) is an evolutionarily conserved zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I). The DNA-binding domain of MTF-1 recognizes a specific DNA sequence termed the metal response element (MRE), located in the promoter/enhancer region of its target genes. Here we show that human MTF-1 forms ho...

In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for cell viability. We provide new insight into the underlying mechanisms, starting from a general model based on ordinary differential equations ...

MTF-1 (metal-responsive transcription factor 1) is an essential mammalian protein for embryonic development and modulates the expression of genes involving in zinc homoeostasis and responding to oxidative stress. We report in the present paper that PTEN (phosphatase and tensin homologue deleted on chromosome 10) associates with MTF-1 in the cells. These two proteins interact via the acidic doma...

Tat activates transcription by interacting with Sp1, NF-kappaB, positive transcription elongation factor b, and trans-activator-responsive element (TAR). Tat and Sp1 play major roles in transcription by protein-protein interactions at human immunodeficiency virus, type 1 (HIV-1) long terminal repeat. Sp1 activates transcription by interacting with cyclin T1 in the absence of Tat. To disrupt the...

Other names: DKFZp547O146; FBI-1; FBI1; LRF; MGC99631; ZBTB7; ZNF857A; pokemon HGNC (Hugo): ZBTB7A Location: 19p13.3 Local order EEF2 (19pter-q12) eukaryotic translation elongation factor 2 SNORD37 (19p13.3) small nucleolar RNA, C/D box 37 PIAS4 (19p13.3) protein inhibitor of activated STAT, 4 ZBTB7A (19p13.3) zinc finger and BTB domain containing 7A MAP2K2 (19q13.3) mitogen-activated protein k...

9. Metal-Responsive MRI Agents 4946 9.1. MRI Agents for Calcium 4946 9.2. MRI Agents for Zinc and Copper 4947 10. Luminescent Metal Complexes for Cellular Imaging 4948 10.1. Luminescent Transition Metal Complexes 4949 10.2. Luminescent Lanthanide Complexes 4950 11. Using Coordination Chemistry To Label Proteins 4951 11.1. Polycysteine Tags 4951 11.2. Polyhistidine Tags 4953 11.3. Polyaspartate ...

High doses of zinc oxide are commonly used in weaned pig diets to improve performance and health. Recent reports show that this may also lead to an imbalanced zinc homeostasis in the animal. For a better understanding of the regulatory mechanisms of different zinc intakes, we performed a feeding experiment to assess potential epigenetic regulation of the ZIP4 gene expression via DNA methylation...

Here we describe a rare clinical manifestation of canine pododemodicosis. A dog was presented with pedal erythema, scaling, crusting, severe edema and digit loss. The following diseases were taken into account for the differential diagnosis: pododemodicosis, lethal acrodermatitis, zinc responsive dermatosis and pemphigus foliaceus. Results from skin biopsies revealed the presence of Demodex spp...