نتایج جستجو برای: zipper
تعداد نتایج: 3644 فیلتر نتایج به سال:
We previously reported that c-Jun binds directly to the N-terminal 163 amino acids of Homo sapiens TATA-binding protein-associated factor-1 (hsTAF1), causing a derepression of transcription factor IID (TFIID)-driven transcription (Lively, T. N., Ferguson, H. A., Galasinski, S. K., Seto, A. G., and Goodrich, J. A. (2001) J. Biol. Chem. 276, 25582-25588). This region of hsTAF1 binds TATA-binding ...
This paper reports results obtained from a study on database validation concerning a leucine zipper motif, utilizing both a functional motif model and a structural motif model. As an example for this method, a leucine tipper motif is chosen, which is a subsequence consists of two twisted alpha helix sequences and preceded by a DNA binding site. For a functional motif model, an HMM (Hidden Marko...
Abstract Background and Aims The global spread of COVID-19 has posed a serious threat to patients receiving renal replacement therapy the staff who treat them. Every time they patient or operate machine, have wear personal protective equipment (PPE). In order reduce burden on our staff, we introduced two pieces equipment. One is hypochlorous acid mist for room surface disinfection using CLFine®...
Several basic leucine zipper (B-ZIP) transcription factors have been implicated in cancer, substance abuse, and other pathological conditions. We previously identified arylstibonic acids that bind to B-ZIP proteins and inhibit their interaction with DNA. In this study, we used electrophoretic mobility shift assay to analyze 46 arylstibonic acids for their activity to disrupt the DNA binding of ...
Human cytomegalovirus (HCMV) UL84 encodes a 75-kDa protein required for oriLyt-dependent DNA replication and interacts with IE2 in infected and transfected cells. UL84 localizes to the nucleus of transfected and infected cells and is found in viral replication compartments. In transient assays it was shown that UL84 can interfere with the IE2-mediated transactivation of the UL112/113 promoter o...
The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carb...
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