At present, patients with advanced Parkinson's disease (PD) are unsatisfactorily controlled by currently used anti-Parkinsonian dopaminergic drugs. Various studies suggest that therapeutic strategies based on nondopaminergic drugs might be helpful in PD. Zolpidem, an imidazopyridine widely used as sleep inducer, shows high affinity only for GABAA receptors containing the α-1 subunit and facilit...

A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of Zolpidem tartrate in bulk and pharmaceutical dosage forms. Zolpidem tartrate shows maximum absorbance at 238.5 nm with molar absorptivity of 4.4648×10lit/mol/cm. Beer’s law was obeyed in the concentration range of 2-16 μg/ml. The limit of detection and limit of quantification were...

STUDY OBJECTIVES To evaluate long-term efficacy and safety of zolpidem extended-release 3 to 7 nights/week for chronic primary insomnia. DESIGN Multicenter, 25-week, phase IIIb, randomized, double-blind, placebo-controlled, parallel-group. SETTING Outpatient; visits every 4 weeks. PATIENTS Aged 18 to 64 years; DSM-IV criteria for chronic primary insomnia; > or =3 months of difficulty init...

Zolpidem is widely prescribed in clinical practice for the treatment of sleep disorders and it is generally considered safe and well tolerated. However, several cases of hallucinations, amnesia, and delirium associated with the use of zolpidem have been reported previously (Ansseau et al., 1992; Katz, 1995; Toner et al., 2000). We present an elderly woman who experienced visual hallucinations a...

Zolpidem is a widely prescribed nonbenzodiazepine hypnotic medication available in the United States since 1992. Attention has been drawn recently to its potential to cause sleep-related, complex behaviors such as sleepwalking and sleep driving. These automatic behaviors have led to a deluge of legal claims. To the authors' knowledge, this is the first review in the forensic literature of the l...

Benzodiazepines allosterically modulate gamma-aminobutyric acid (GABA) evoked chloride currents of gamma-aminobutyric acid type A (GABAA) receptors. Coexpression of either rat gamma2 or gamma3, in combination with alpha1 and beta2 subunits, results both in receptors displaying high [3H]Ro 15-1788 affinity. However, receptors containing a gamma3 subunit display a 178-fold reduced affinity to zol...

OBJECTIVES To evaluate the risk of fractures related with zolpidem in elderly insomnia patients. METHODS Health claims data on the entire South Korean elderly population from January 2005 to June 2006 were extracted from the Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases were defined as insomnia patients who had a fracture diagnosis. We set ...