The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal polarity.

This article examines New York City’s first attempt to regulate adult entertainment establishments through zoning provisions. Specifically, it discusses whether the adult-use zoning provisions comply with federal and state constitutional requirements, and it examines whether the adult-use amendments would cause a reduction in adult-use establishments in New York City, which would render the ame...

This paper investigates different strategies allowing integration of contextual information during the feature extraction stage of a cursive handwriting HMM-based recognition system. First we propose to use linear discriminant analysis (LDA) in order to integrate the class information during feature set building. Secondly several zoning strategies are used to integrate local contextual informat...

FEW analytical data exist for staurolite, in comparison with other metamorphic minerals such as garnet. However, using the microprobe, Hollister and Bence (1967) working with relatively inclusion-free specimens from the Kwoiek Area, British Columbia, established compositional zoning across staurolite in addition to compositional irregularities across sectoral twin boundaries. The staurolites st...

Oscillatory zoning, i.e., self-formation of spatial quasiperiodic oscillations in the composition of solid growing from aqueous solution, is analyzed theoretically. Keeping in mind systems like (Ba,Sr)SO4 , we propose a one-dimensional model that takes into account the nonideality of the solid solution and the system asymmetry, in particular, reflecting itself in different solubilities for such...

Zoning is widely used for obtaining topological features of handwritten characters. In this paper we have modified the zoning criteria using fuzzy boundary of individual zones keeping the point in mind that writing style of different persons may shift the structural pattern of the character from one zone to the adjacent zone. The zone-wise normalized distance of individual black pixel along wit...

This paper presents a two-level based character recognition method in which a dynamically selection of the most promising zoning scheme for feature extraction allows us to obtain interesting results for character recognition. The first level consists of a conventional neural network and a look-up-table that is used to suggest the best zoning scheme for a given unknown character. The information...

This paper describes the development and applications of a computational tool, referred to as the Multi-Objective Zoning and AggRegation Tool (MOZART), for devising optimal zoning systems. MOZART aims to account for a diverse range of criteria that may arise in customising zones to suit different contexts. This flexibility is achieved by treating the problem of zone design as a problem of parti...

Economists have long argued that systems of marketable permits are a cost-effective means of regulating externalities. Though these ideas have only recently been implemented in the field of pollution control, transferable development rights (TDRs) have been used for decades by city planners in many locales. Most opponents of permit trading contest the granting of property rights to the originat...