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Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration and medium additives can individually and interactively influence the structure, composition, mechanical, and molecular properties of engineered tissues based on hMSCs and 3D poly(ɛ-caprolac...
In general, there are three components making up a lightning protection system for wind turbines. These are the receptors, the down conductor and the grounding grid. Receptors and down conductors are usually found in the more recent wind turbine blades and where the down conductors are normally installed on the internal side of the blade. Consequently, the blades are vulnerable to damage and bu...
Advanced glycation end products (AGEs) accumulate in the aging skin. To understand the biological effects of individual AGEs, skin reconstructed with collagen selectively enriched with N(ɛ)-(carboxymethyl)-lysine (CML), N(ɛ)-(carboxyethyl)-lysine (CEL), methylglyoxal hydroimidazolone (MG-H1), or pentosidine was studied. Immunohistochemistry revealed increased expression of α6 integrin at the de...
BACKGROUND The formulation of docetaxel available for clinical use (Taxotere) contains a high concentration of polysorbate 80 (Tween 80). After incorporation of Tween 80 into poly-ɛ-caprolactone (PCL)-Tween 80 copolymer, the relative amount of Tween 80 should be decreased and the advantages of PCL and Tween 80 should be combined. METHODS A novel PCL-Tween 80 copolymer was synthesized from ɛ-c...
We examine the nature of ac electrowetting (EW)-driven axisymmetric oscillations of a sessile water drop on a dielectric substrate. In ac EW, small-amplitude oscillations of a drop differ from the Rayleigh linear modes of freely oscillating drops. In this paper, we demonstrate that changes in the time-averaged contact angle of the sessile drop attributed to the presence of an electric field and...
The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD mutations increase the release of amyloid β (Aβ)42 relative to Aβ40 by an unknown, possibly gain-of-toxic-function, mechanism. However, many PSEN mutations paradoxically impair γ-secretase and 'loss-of-function' mechanisms have al...
Spectral contrast effects, the perceptual magnification of spectral differences between sounds, have been widely shown to influence speech categorization. However, whether talker information alters spectral contrast effects was recently debated [Laing, Liu, Lotto, and Holt, Front. Psychol. 3, 1-9 (2012)]. Here, contributions of reliable spectral properties, between-talker and within-talker vari...
New initiating systems based on silane (diphenylsilane (DPSi)) and/or amine (triethylamine (TEA)) and gold salt (Gold(III) chloride trihydrate (HAuCl4)) are proposed for an easy thermal cationic and/or radical polymerization of ɛcaprolactone (ɛ-CL) and trimethylolpropane triacrylate (TMPTA) at room temperature and under air. They ensure good to excellent polymerizations. Moreover, a direct inco...
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