INTRODUCTION Prenatal screening and diagnosis is important for the detection of birth defects and genetic diseases. The nationwide proficiency testing (PT) of maternal serum prenatal screening in second trimester in China has been launched since 2003 and partly reflected the performance of screening laboratories. This study analysed the 2015 PT results to examine the performance of clinical lab...

OBJECTIVE To investigate the efficacy of methotrexate (MTX) injection in treatment of cesarean scar pregnancy (CSP). METHOD A randomized controlled study was performed in 104 CSP patients receiving either local or systemic MTX injection at the Peking Union Medical College Hospital from the year 2008 to 2013. RESULTS Complete cure was defined as regression of ultrasonographic findings and no...

OBJECTIVE To evaluate the effectiveness of urea, creatinine, prolactin, and the beta sub-unit of human chorionic gonadotropin (β-hCG) of vaginal fluid in the diagnosis premature preterm rupture of membranes (PROM). MATERIALS AND METHODS In this observational study, 160 pregnant women with gestational age of 28 to 40 weeks were divided into two equal groups: investigation (documented PROM) and...

Objective-Preeclampsia is one of the leading cause of maternal mortality and morbidity worldwide. The purpose of this study was to determine the level of β hCG and other biochemical markers in preeclampsia and in normotensive patients . Method – This was a prospective study conducted on 50 preeclamptic (case)and 50 normotensive pregnant women (control) in obstetrics and gynaecology department o...

OBJECTIVE Detection of factors that affect the success of single-dose methotrexate treatment in ectopic pregnancy. MATERIALS AND METHODS We investigated 99 patients who had been treated with single-dose methotrexate for ectopic pregnancy in our clinic between January 2009 and June 2014. Demographic, clinical, and laboratory results of possible factors that affect treatment success were retros...

Osteosarcoma is the most common malignant bone tumor in children and young adults and is associated with high mortality. We investigated the expression of βhCG and P16 in osteosarcoma and correlated with outcomes. Methods: Immunohistochemistry (IHC) for β-hCG was performed on diagnostic osteosarcoma specimens and post-treatment specimens. IHC for P16 was performed on diagnostic specimens. Resul...