Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites and the target of the quinoline class of antimalarials. Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. Among them are the identity of the crystallization medium in vivo, aqueous or organic; the mechanism of crystallization, clas...

Heme levels and growth of malignant murine erythroleukemia cells in heme-free medium are drastically reduced by incubation of these cells in the presence of 4,6-dioxoheptanoic acid [succinylacetone (SA)]. When hematin was added to the culture medium of heme-depleted cells, the intracellular heme levels returned to normal, and growth inhibition produced by SA was also reversed. However, when cel...

Freshly prepared alkaline hematin inhibits the growth of many Grampositive organisms, including Bacillus anthracis; Gram-negative organisms, however, are generally not inhibited. Work on a selective medium for isolating B. anthracis that does not contain hematin as a selective ingredient is in progress.

Abstract Background Achillea filipendulina (L.) is an important medicinal plant and Asian species of the Asteraceae family. A. that grows in Central Southwest Asia. It was chosen for study with aim screening biologically active compounds essential oil aerial parts antioxidant, antimalarial xanthine oxidase inhibitory activities its extract. Essential extracted by using Clevenger apparatus. Extr...

Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against the parasite. Objective: To determine the immunological impact of hemozoin on the capacity ...