Abstract The atypical IκB family member Bcl3 associates with p50/NF-κB1 or p52/NF-κB2 homodimers in the nucleus, and positively negatively modulates transcription a context-dependent manner. Since expression dendritic cells (DC) is pivotal for antigen presentation since classical DCs (cDC) are major presenting cells, we investigated role of specifically cDCs vivo by crossing Zbtb46 cre mice Bcl...