Significant progress has been achieved in making larger (2 inch) 4H-SiC substrates with much lower micropipe defect densities. With the recent availability of semi-insulating 4H-SiC substrates, the demonstration of impressive microwave power results have been made possible both in SiC MESFETs and in GaN/AlGaN HEMTs grown on these substrates. SiC MESFETs have achieved RF power densities of 4.6 W...

Percutaneous invasion of coronary arteries began with Andreas Gruentzig, who performed the first human percutaneous transluminal coronary angioplasty (PTCA). Stents, which overcame many of the limitations encountered with PTCA alone, were the next big milestone in the field of interventional cardiology. However, the incidence of restenosis even with stents remained high, at 20–40%. Over time, a...

Cytochrome P450 (CYP) 2J2 is one of the human CYPs involved in phase I xenobiotics metabolism. It is mainly expressed in extrahepatic tissues, including intestine and cardiovascular systems. The general role of CYP2J2 in drug metabolism is not yet fully understood, and the recent discovery that CYP2J2 can metabolize a wide range of structurally diverse drugs and its primary distribution in the ...

We present an extension of the standard partition function approach to RNA secondary structures that computes the probabilities Pu[i, j] that a sequence interval [i, j] is unpaired. Comparison with experimental data shows that Pu[i, j] can be applied as a significant determinant of local target site accessibility for RNA interference (RNAi). Furthermore, these quantities can be used to rigorous...

The California Stem Cell Research and Cures Act, also called Proposition 71 [5], was a ballot initiative proposed by California voters in 2004 to allocate three billion dollars of state funds for stem cell research over ten years. Endorsed by California scientists and patient-advocates, Prop 71 passed on 2 November 2004, amending the state constitution to make stem cell research a constitutiona...

The California Stem Cell Research and Cures Act, also called Proposition 71 [5], was a ballot initiative proposed by California voters in 2004 to allocate three billion dollars of state funds for stem cell research over ten years. Endorsed by California scientists and patient-advocates, Prop 71 passed on 2 November 2004, amending the state constitution to make stem cell research a constitutiona...

1Departments of Medicine and Dermatology, Division of Immunology and Rheumatology, Stanford University and Palo Alto VA Health Care System, CA, USA; 2Centre for Rheumatology, Royal Free Hospital, London, United Kingdom; 3Department of Rheumatology, University Hospital Zurich, Switzerland; 4Department of Medicine, Division of Rheumatology, University of California at Los Angeles, Los Angeles, US...

Hand, foot and mouth disease (HFMD) is a common illness of infants and young children <10 years of age. It is characterized by fever, ulcers in the oral cavity, and rashes with blisters that appear on the palm and sole. The most common causal agents of HFMD are coxsackievirus A16 (CV-A16) and human enterovirus 71 (HEV71), but other enteroviruses, including CV-A5 and CV-A10, can also cause it. W...