BACKGROUND Cystine-knot (cys-knot) structure is found in a rather large number of secreted proteins and glycoproteins belonging to the TGFbeta and glycoprotein hormone (GPH) superfamilies, many of which are involved in endocrine control of reproduction. In these molecules, the cys-knot is formed by a disulfide (SS) bridge penetrating a ring formed by 8, 9 or 10 amino-acid residues among which f...

the climate and weather patterns of buffalo (new york, u.s.a.) are strongly influenced by thecity’s proximity to lake erie. total monthly snowfall in buffalo is forecasted using neural network techniques(multi-layer perceptron = mlp) and a multiple linear regression (lr) model. the period of analysis comprises 28 years from january 1982 to december 2009. input data include: zonal wind speed (u-...

General purpose computing architectures are evolving quickly to become manycore and hierarchical: i.e. a core can communicate more quickly locally than globally. To be effective on such architectures, programming models must be aware of the communications hierarchy. This thesis investigates a programming model that aims to share the responsibility of task placement, load balance, thread creatio...

We propose a flexible procedure for large-scale image search by hash functions with kernels. Our method treats binary codes and pairwise semantic similarity as latent and observed variables, respectively, in a probabilistic model based on Gaussian processes for binary classification. We present an efficient inference algorithm with the sparse pseudo-input Gaussian process (SPGP) model and paral...

SymGrid-Par is a new framework for executing large computer algebra problems on computational Grids. We present the design of SymGrid-Par, which supports multiple computer algebra packages, and hence provides the novel possibility of composing a system using components from different packages. Orchestration of the components on the Grid is provided by a Grid-enabled parallel Haskell (GpH). We p...

algebra is one of the most powerful unifying paradigms of twentieth century mathematics. A vast field of research in its own right, it is also a key tool in other areas of mathematics, in physics, in chemistry and in computer science. In the last thirty years, computational tools have played an increasing role in the development and application of abstract algebra, until today, computational al...

Parallel programs must describe both computation and coordination , i.e. what to compute and how to organize the computation. In functional languages equational reasoning is often used to reason about computation. In contrast, there have been many diierent coordination constructs for functional languages, and far less work on reasoning about coordination. We present an initial semantics for GpH...

String players know that bowing properly is the hardest skill they have to learn. In other work 4], we develop an algorithm that calculates bowings for BowTech, a project that supports string performers. This algorithm takes a signiicant amount of time to execute (in our second test case, over an hour for the implementation, written in Ada). We have implemented the algorithm in GpH, a parallel ...

This paper reexamines foreign currency markets for evidence of fractional integration, and extends the extant literature in several important dimensions. First, we utilize a new semiparametric wavelet-based estimator, which is far superior to the more prevalent GPH estimator on the basis of mean squared error. Second, we utilize a broader and longer sample, which better facilitates the detectio...