BACKGROUND We developed a genetic risk score (GRS) and examined whether the GRS may predict incident stage 3 chronic kidney disease (CKD) independent of common clinical risk factors. METHOD The present study included 2,698 individuals who attended the 15th (1977 to 1979) and the 24th exams (1995 to 1998) in the Framingham Original cohort or the 6th (1995 to 1998) and the 8th exams (2005 to 20...

BACKGROUND Simulation has been identified as a means of assessing resident physicians' mastery of technical skills, but there is a lack of evidence for its utility in longitudinal assessments of residents' non-technical clinical abilities. We evaluated the growth of crisis resource management (CRM) skills in the simulation setting using a validated tool, the Ottawa Crisis Resource Management Gl...

Rates of commitment to germinate and germination of Bacillus subtilis spores with mixtures of low concentrations of germinants acting on different germinant receptors (GRs) were much higher than the sums of the rates of commitment and germination with individual germinants alone. This synergism with mixtures of nutrient germinants was not seen with spores lacking GRs responsible for recognizing...

BACKGROUND Patients with type 2 diabetes (T2D) are at elevated risk for cardiovascular disease (CVD) events and mortality. Recent studies have assessed the impact of genetic variants affecting high-density lipoprotein cholesterol (HDL) concentrations on CVD risk in the general population. This study examined the utility of HDL-associated single nucleotide polymorphisms (SNPs) for CVD risk predi...

OBJECTIVE Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested if a GRS based on an updated list of 34 type 2 diabetes-associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes P...

Several different approaches are available to clinicians for determining prostate cancer (PCa) risk. The clinical validity of various PCa risk assessment methods utilizing single nucleotide polymorphisms (SNPs) has been established; however, these SNP-based methods have not been compared. The objective of this study was to compare the three most commonly used SNP-based methods for PCa risk asse...

Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel respons...

We discuss the compatibility between the weaker energy condition and the stability of Gregory, Rubakov and Sibiryakov (GRS) model. Because the GRS spacetime violates the weak energy condition, it may cause the instability. In the GRS model, the four dimensional gravity can be described by the massive KK modes with the resonance. Hence, instead of considering the weaker energy condition, we requ...

I summarize recent near-infrared spectroscopy of the microquasar GRS 1915+105 with the ESO/VLT which allowed to (i) identify the donor and (ii) measure the orbital period and radial velocity amplitude. Assuming that the jet ejections occur perpendicular to the accretion disk and orbital plane, the mass of the black hole is determined to M = 14 ± 4 M⊙. I discuss the implications of this mass det...

To facilitate the use of syntactic information in the study of child language acquisition, a coding scheme for Grammatical Relations (GRs) in transcripts of parent-child dialogs has been proposed by Sagae, MacWhinney and Lavie (2004). We discuss the use of current NLP techniques to produce the GRs in this annotation scheme. By using a statistical parser (Charniak, 2000) and memorybased learning...