We present and compare adaptive detection algorithms developed for synthetic aperture radar (SAR) targets in structured clutter, utilizing both generalized likelihood ratio (GLR) tests and maximal invariant (MI) tests. We consider the problem of detecting a target straddling a known boundary between two independent clutter regions inducing a clutter covariance matrix with block diagonal structu...

The problem of detecting changes in a stochastic system is addressed. When the model parameters after the change are unknown the generalized likelihood ratio (GLR) scheme is usually used to solve the problem. This scheme is asymptotically optimal but it is also particularly time-consuming which makes questionable its real time implementation. The window-limited GLR scheme, which takes into acco...

A primary determinant of the strength of neurotransmission is the number of AMPA-type glutamate receptors (AMPARs) at synapses. However, we still lack a mechanistic understanding of how the number of synaptic AMPARs is regulated. Here, we show that UNC-116, the C. elegans homolog of vertebrate kinesin-1 heavy chain (KIF5), modifies synaptic strength by mediating the rapid delivery, removal, and...

There has been considerable recent interest in applying maximal invariant (MI) hypothesis testing as an alternative to the generalized likelihood ratio (GLR) test. This interest has been motivated by several attractive theoretical properties of MI tests including: exact robustness to variation of nuisance parameters, finitesample min-max optimality (in some cases), and distributional robustness...

The process of iterative structure-based drug design involves the X-ray crystal structure determination of upwards of 100 ligands with the same general scaffold (i.e. chemotype) complexed with very similar, if not identical, protein targets. In conjunction with insights from computational models and assays, this collection of crystal structures is analyzed to improve potency, to achieve better ...

Regulated endocytosis of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) is critical for synaptic plasticity. However, the specific combination of clathrin-dependent and -independent mechanisms that mediate AMPAR trafficking in vivo have not been fully characterized. Here, we examine the trafficking of the AMPAR subunit GLR-1 in Caenorhabditis elegans....

Additive models with backfitting algorithms are popular multivariate nonparametric fitting techniques. However, the inferences of the models have not been very well developed, due partially to the complexity of the backfitting estimators. There are few tools available to answer some important and frequently asked questions, such as whether a specific additive component is significant or admits ...

This chapter describes GLR*, a parser that can parse any input sentence by ignoring unrecognizable parts of the sentence. Using an eecient algorithm, the parser is capable of nding and parsing a maximal subset of the original input that is parsable, and therefore return the parse with fewest skipped words. The parser returns some parse(s) for any input sentence, unless no part of the sentence c...

Glued mutations in Drosophila comprise an essential complementation group with complex developmental effects. The original Glued mutation (Gl) has dominant nonlethal effects in heterozygous flies, principally on the morphogenesis of the visual system. Gl also has a recessive lethal effect early in development. Mutations that reverse the dominant visual effects of Gl (GlR mutations) were induced...

The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that targets key cell cycle regulatory proteins for degradation. Blockade of APC activity causes mitotic arrest. Recent evidence suggests that the APC may have roles outside the cell cycle. Several studies indicate that ubiquitin plays an important role in regulating synaptic strength. We previously showed that ubiquitin...