The protein products of the fos (Fos) and jun (Jun) proto-oncogenes have been shown to associate with a DNA element known as the transcription factor activator protein-1 (AP-1) binding site. Jun (previously known as the Fos-binding protein p39) and Fos form a protein complex in the nucleus. To investigate the nature of the association of Fos and Jun with the AP-1 site, and to determine the role...

Capsaicin treatment destroys vagal afferent C fibers and markedly attenuates reduction of food intake and induction of hindbrain Fos expression by CCK. However, both anatomical and electrophysiological data indicate that some gastric vagal afferents are not destroyed by capsaicin. Because CCK enhances behavioral and electrophysiological responses to gastric distension in rats and people, we hyp...

Vizzard, Margaret A. Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis. Am J Physiol Regulatory Integrative Comp Physiol 278: R1027–R1039, 2000.—These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after cyclophosphamide (CYP)-induced bladder inflammation. In uret...

PURPOSE To address the effects of fructooligosaccharides (FOS) intake on serum cholesterol levels. METHODS We performed a search for scientific articles in MEDLINE database from 1987 to 2014, using the following English keywords: fructooligosaccharides; fructooligosaccharides and cholesterol. A total of 493 articles were found. After careful selection and exclusion of duplicate articles 34 re...

Expression of the fos family of transcription factors is stimulated by growth factors that induce quiescent cells to reenter the cell cycle, but the cellular targets of the Fos family that regulate cell cycle reentry have not been identified. To address this issue, mice that lack two members of the fos family, c-fos and fosB, were derived. The fosB-/- c-fos-/- mice are similar in phenotype to c...

We examined the effects of i.c.v. administration of neuro-peptide W-30 (NPW30) on plasma arginine vasopressin (AVP) and plasma oxytocin (OXT) using RIA. The induction of c-fos mRNA, AVP heteronuclear (hn)RNA, and c-Fos protein (Fos) in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of rats were also investigated using in situ hybridization histochemistry for c-fos mRNA and AVP h...

One of the largest problems facing rural school counselors is that of confronting the low career expectations that many rural students have by the time they reach high school. The relationship among the fear of success (FOS), self-concept, and career decision making of adolescents was examined in this study. Special attention was given to whether or not the sex difference for FOS as reported fo...

Abstract Introduction Fear of sleep (FoS) is linked to symptoms PTSD. Additionally, cognitive behavioral therapy for insomnia (CBTi) can reduce FoS. Utilizing data from a randomized controlled trial CBTi followed by Cognitive Processing Therapy PTSD (CPT), this secondary analysis sought examine the relationship between FoS and symptoms, how impacted CBTi, in individuals exposed interpersonal vi...

The c-fos gene encodes a basic region-leucine zipper transcription factor that requires heterodimerization with a member of the Jun family for stable DNA binding. Fos/Jun heterodimers are present in the AP-1 transcription factor complex and both c-Fos and c-Jun are capable of transforming cells (1). Continuous expression of c-fos can lead to aberrant differentiation (2) but may also sometimes b...