The p53 tumor suppressor is an essential barrier against cancer, which is evidenced by loss of p53 activity in the majority of human cancers and unexceptionally early onset of tumors in p53-knockout mice and human Li-Fraumeni syndrome patients. p53 is a sequence-specific transcription factor that regulates gene expression via binding to the consensus p53-responsive element (p53-RE). p53 acts as...

nloaded ection of circulating tumor cells (CTC) is advancing as an effective predictor of patient outcome and eutic response. Unfortunately, our knowledge of CTC biology remains limited, and the impact of treatments on CTC metastatic potential is currently unclear. Improved CTC imaging in vivo and is of free-floating tumor cells now show that cytoskeletal regulation in CTCs contrasts starkly wi...

This paper presents the MIC∗ algebraic structure modelling an environment where autonomous, interacting and mobile entities evolve.

Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have been shown to overcome these barriers. We synthesized investigated activity series unsymmetrical MACs derived from acetone against Mycobacterium tuberculosis Gram-ne...

Contract Type Contract Number Jurisdiction State(s) Noridian Healthcare Solutions, LLC A and B MAC 02101 MAC A J F Alaska Noridian Healthcare Solutions, LLC A and B MAC 02102 MAC B J F Alaska Noridian Healthcare Solutions, LLC A and B MAC 02201 MAC A J F Idaho Noridian Healthcare Solutions, LLC A and B MAC 02202 MAC B J F Idaho Noridian Healthcare Solutions, LLC A and B MAC 02301 MAC A J F Oreg...

Abstract. The theory of morality as cooperation (MAC) argues that there are seven distinct and evolved universal moral foundations. Curry, Chesters, Van Lissa (2019) developed a scale to test this theoretical approach showed the Relevance subscale MAC questionnaire (MAC-Q) fits data well, unlike Judgment full-form. However, an independent validity has not been hitherto conducted, its relation w...