OBJECTIVE The current study aims to replicate western reports of a familial excess of syndromal and sub-syndromal Obsessive Compulsive Disorder (OCD) in OCD probands in an Indian population. METHOD 148 relatives of OCD probands were compared with 151 normal subjects, based on evaluation on Schedule for Clinical Assessment for Neuropsychiatry (SCAN). RESULTS There were no clinically signific...

Sir: Cognitive-behavioral therapy (CBT) has repeatedly been found to be effective in the treatment of obsessive-compulsive disorder (OCD), 1 and the Expert Consensus Guidelines for the Treatment of OCD 2 recommend CBT as a first-line treatment of adult OCD along with serotonin reuptake–inhibiting drugs. However, many OCD sufferers never receive adequate CBT treatment; for example, Mancebo et al...

IMPORTANCE Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties. OBJECTIVES To determine regions of abnormal degree connectivity in patients with OCD and to investigate whether connectivity m...

It is widely agreed that obsessive-compulsive disorder involves irrationality. But where in the complex of states and processes constitutes OCD should this irrationality be located? A pervasive assumption both psychiatric philosophical literature seat located obsessive thoughts characteristic OCD. Building on a puzzle about insight into OCD, we challenge assumption, argue instead emotions are s...

OBJECTIVE The aim of this study was to determine the childhood clinical predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder (OCD) and to assess whether dimensional subtypes of OCD and the presence of comorbid tic symptoms influence long-term outcomes. METHODS We conducted a longitudinal cohort study in which 45 of 62 eligible children with OCD were reassessed a...

Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) are frequently co-morbid, and dysfunctional frontal-striatal circuits have been implicated in both disorders. Neurobiological distinctions between OCD and MDD are insufficiently clear, and comparative neuroimaging studies are extremely scarce. OCD and MDD may be characterized by cognitive rigidity at the phenotype level, an...

BACKGROUND Dysfunction of frontal-striatal, particularly orbitofrontal-striatal, circuitry has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD), characterized by obsessions, ritualistic behavior, anxiety, and specific cognitive impairments. In addition, neuropsychological studies in OCD have reported impairments in visuospatial tasks and executive functions, such as...

BACKGROUND Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophreni...

BACKGROUND Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables. METHODS We...