background:   materials and methods: this was a cross-sectional study carried out among 70 samples, including 10 samples from normal healthy mucosa categorized into group 1, group 2 (30 olp), and group 3 (30 oed) samples. five sections (4 μm thick) were obtained and stained with monoclonal antibodies such as ki-67, p53, bcl-2, and bax and analyzed for number of positive cells and also for inten...

Abstract B-cell lymphoma X-large (BCL-XL) has been shown to promote breast cancer metastasis independently of its anti-apoptotic function. We recently found that proteolysis-targeting chimeras (PROTACs) against BCL-XL kill cells as well tumor-induced regulatory T (TI-Tregs). BCL-XL-targeting PROTACs can be potentially used treat metastatic – by direct killing circulating tumor at their vulnerab...

Excessive apoptosis of intervertebral disk cells and degeneration (IDD) is the prime cause low back pain. B-cell lymphoma 2 (Bcl-2) adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member Bcl-2 family, are involved in cell autophagy apoptosis. The roles mechanisms BNIP3 unclear. In this study, primary rat were prepared to study effect overexpression on their counting kit (CCK)-8 assay sho...

The paper aimed to investigate the effects of up-regulation and down-regulation Mir-299-3p on proliferation, migration, invasion apoptosis lung adenocarcinoma cell line H1299, preliminarily explore mechanism regulating biological behavior cells. inhibitor mimics were transfected into transfection efficiency was measured by fluorescence microscopy. successfully cells detected invasion, apoptosis...

Introduction: Cardiomyocytes apoptosis contributes to the development of left ventricular hypertrophy. The Bcl-2 family members are important regulators of mitochondrial pathway of apoptosis. Monoterpenoid phenol –carvacrol– possesses strong antioxidant properties. The present study aimed to evaluate the effect of carvacrol on transcription level of pro-apoptotic (Bad and Bax) and...

The organization and expression of the BCL-6 gene in normal and neoplastic thymic T cells has not been fully determined. We examined 8 precursor T-cell lymphoblastic lymphomas (T-LBLs) and found significant BCL-6 expression in 4 cases. Three of the BCL-6(+) cases expressed a common thymocyte phenotype (CD4(+), CD8(+)), and one expressed a precursor thymocyte phenotype (CD4(-), CD8(-)). In 6 cas...

In 2018, China contributed to 7.8% of the global drug innovation pipeline and 11.6% new launches, thereby becoming largest base for R&D in Asia. Statistically, oncology, particularly field lymphoma, occupies major area innovative development. Despite substantial advances, there is still an unmet need develop better therapies B-cell lymphomas (BCL), especially those incurable settings. As icon s...

urokinase plasminogen activator receptor (upar) and its ligands play a major role in many tumors by mediating extracellular matrix degradation and signaling cascades leading to tumor growth, invasion and metastasis. recently we introduced upar decapeptide antagonist with cytotoxic effect on mda-mb-231 cell line. in this study we assessed the alteration in upar downstream signaling following tre...