In this paper, we present a certificateless signature (CLS) scheme that is proved to be secure in the random oracle model under the hardness assumptions of k-CAA and Inv-CDHP. Our scheme upholds all desirable properties of previous CLS schemes, and requires general cryptographic hash functions instead of the MapToPoint hash function which is inefficient and probabilistic. Furthermore, our schem...

Numerous proposals have surfaced recently to incorporate a labor-standards clause into the rules of the World Trading Organization (WTO). Such a clause would require recognition and enforcement by each WTO member of certain core labor standards (CLS): freedom from forced labor, absence of discrimination, elimination of exploitative use of child workers, and rights of workers to associate freely...

Driven by the promises of gene therapy, PEGylated cationic liposomes (CLs) have been investigated for decades, but their use in the clinical setting is far from established. Such a dichotomy is due to several factors that have been ignored over the last two decades. The hardest challenge seems to occur when PEGylated CLs come into contact with a physiological environment (e.g. the blood). Recen...

Simultaneous spectrophotometric analysis of a multi-component dosage form of olmesartan, amlodipine and hydrochlorothiazide used for the treatment of hypertension has been carried out using various chemometric methods. Multivariate calibration methods include classical least squares (CLS) executed by net analyte processing (NAP-CLS), orthogonal signal correction (OSC-CLS) and direct orthogonal ...

Coffin-Lowry Syndrome (CLS) is an X-linked mental retardation condition associated with skeletal abnormalities. The gene mutated in CLS, RSK2, encodes a growth factor-regulated kinase. However, the cellular and molecular bases of the skeletal abnormalities associated with CLS remain unknown. Here, we show that RSK2 is required for osteoblast differentiation and function. We identify the transcr...

Cardiolipin (CL) is a phospholipid localized to the mitochondria, and its biosynthesis is essential for mitochondrial structure and function. We report here the identification and characterization of a cDNA encoding the first mammalian cardiolipin synthase (CLS1) in humans and mice. This cDNA exhibits sequence homology with members of a CLS gene family that share similar domain structure and ch...

We explore different applications of Canonical Least Squares (CLS) clustering on a corpus of sparse medical claims from a particular health insurance provider. We find that there are several reasons why most conclusions based on CLS clusters might be misleading, especially when the data is significantly sparse. We illustrate these findings by performing a number of synthetic experiments with th...

Using connectionless servers (CLS) is one way to provide connectionless services in ATM networks. Number and location of these CLSs must be carefully selected because of their significant influence on the performance of the connectionless data traffic. In this paper a method is presented that is able to propose a minimum CLS set necessary to achieve a certain performance in arbitrary ATM networ...

The present study characterizes the dynamic interfacial properties of calf lung surfactant (CLS) and samples reconstituted in a stepwise fashion from phospholipid (PL), hydrophobic apoprotein (HA), surfactant apoprotein A (SP-A), and neutral lipid fractions. Dipalmitoylphosphatidylcholine (DPPC), the major PL component of surfactant, was examined for comparison. Surface tension was measured ove...

Obesity is frequently associated with a chronic low-grade inflammation within adipose tissue (AT). Although classical signs of inflammation are missing in AT inflammation, there is a significant increase in macrophages and, to a lesser extent, other immune cells, such as T cells, B cells, mast cells, and neutrophils. The spatial and temporal activation of these cells as well as their accumulati...