In a previous study of 20 patients with Merkel cell carcinoma (MCC) we reported that p53 appeared to be positive in specimens from patients with a poor clinical outcome (2). The antibody we used to detect p53 protein, clone PAb1801 (Oncogene Science, Cambridge, Mass.), does not distinguish between mutant and wild-type epitopes of p53. We assumed that, since wild-type p53 is thought to be transi...

Web Application Firewalls (WAFs) are used to detect and block attacks against vulnerable web applications. They distinguish benign requests from rogue requests using a set of filter rules. We present a new timing side channel attack that an attacker can use to remotely distinguish passed requests from requests that the WAF blocked. The attack works also for transparent WAFs that do not leave an...

αβ and γδ lineage T cells are thought to arise from a common CD4(-)CD8(-) progenitor in the thymus. However, the molecular pathways controlling fate selection and maturation of these two lineages remain poorly understood. We demonstrated recently that a ubiquitously expressed ribosomal protein, Rpl22, is selectively required for the development of αβ lineage T cells. Germline ablation of Rpl22 ...

Risks posed by oil spills to coral reefs are difficult to evaluate, partially due to the absence of studies that adequately assess toxicity to relevant coral reef species. Here we experimentally tested the acute toxicity of condensate, representing a fraction of light crude oil, to coral (Acropora tenuis) and sponge (Rhopaloeides odorabile) larvae. The metamorphosis of coral larvae was inhibite...

in this paper, a new implicit nonstandard finite difference scheme for conservation laws, which preserving the property of tvd (total variation diminishing) of the solution, is proposed. this scheme is derived by using nonlocal approximation for nonlinear terms of partial differential equation. schemes preserving the essential physical property of tvd are of great importance in practice. such s...

OBJECTIVES The purpose of this retrospective study was to assess long-term outcome of children after surgical closure of a ventricular septal defect (VSD). MATERIAL AND METHODS Between January 1992 and December 2001 a consecutive series of 188 patients (100 females) were operated for closure of a VSD. Temporary tricuspid valve detachment (TVD) was applied in 46 patients (24%) to enhance expos...

In this paper we analyse the consistency, the accuracy and some entropy properties of particle methods with remeshing in the case of a scalar one-dimensional conservation law. As in [7] we re-write particle methods with remeshing in the finite-difference formalism. This allow us to prove the consistency of these methods, and accuracy properties related to the accuracy of interpolation kernels. ...

INTRODUCTION Truvada® (TVD) was approved in July 2012 by the US FDA for pre-exposure prophylaxis (PrEP) in combination with safer sex practices to reduce the risk of sexually acquired HIV-1 in high-risk adults. This study explores the characteristics of US PrEP users and their prescribers over the past two years. MATERIALS AND METHODS A previously described algorithm was used to identify TVD ...

BACKGROUND Despite its widespread use in pulmonary fibrosis research, the bleomycin mouse model has not been thoroughly validated from a pulmonary functional standpoint using new technologies. Purpose of this study was to systematically assess the functional alterations induced in murine lungs by fibrogenic agent bleomycin and to compare the forced oscillation technique with quasi-static pressu...

BACKGROUND Angiographic studies have shown that the extent of disease and severity is less in younger population with comparatively fewer number of coronary arteries affected than that of older age groups. This study was conducted to compare the pattern of coronary artery disease (CAD) in young adults under 40 years and those more than 40 years of age with significant coronary artery disease on...