نتایج جستجو برای: ساکل cx

تعداد نتایج: 3746  

2017
Hong Xu Marco Di Antonio Steven McKinney Veena Mathew Brandon Ho Nigel J O'Neil Nancy Dos Santos Jennifer Silvester Vivien Wei Jessica Garcia Farhia Kabeer Daniel Lai Priscilla Soriano Judit Banáth Derek S Chiu Damian Yap Daniel D Le Frank B Ye Anni Zhang Kelsie Thu John Soong Shu-Chuan Lin Angela Hsin Chin Tsai Tomo Osako Teresa Algara Darren N Saunders Jason Wong Jian Xian Marcel B Bally James D Brenton Grant W Brown Sohrab P Shah David Cescon Tak W Mak Carlos Caldas Peter C Stirling Phil Hieter Shankar Balasubramanian Samuel Aparicio

G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect. Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BRCA deficiencies in cancer cells and polyclonal patient-derived xenograft models, including tumours resis...

2006
Takuji Tanaka Hiroki Makita Masaini Ohnishi Hideki Mori Kumiko Satoh Akira HarÃ

The chemopreventive effects of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) on oral Carcinogenesis induced by 4-nitroquinoline I-oxide (4-NQO) was investigated in male F344 rats. Rats were given 20 ppm of 4-NQO in their drinking water for 8 weeks to induce oral neo plasms or preneoplasms. Animals were fed diets containing 100 ppm AX or CX during the initiation or postinitiation pha...

2000
Dhavalkumar D. Patel Lili Feng Thomas M. Coffman David N. Howell Robert Griffiths Victoria Bautch Lisa A. Robinson Chandra Nataraj Dennis W. Thomas

2007
H. H. VAN GELDEREN L. J. DOOREN

The determination of the total content of free a-amino acids in urine has become routine in paediatric practice in numerous diseases. Interest in aminoaciduria has greatly increased since it became known that many congenital metabolic disorders are accompanied by an increased excretion of free oc-amino acids in the urine (Paine, 1960; Woolf, 1961). The excretion of free a-amino-N is usually exp...

Journal: :International Journal of Contemporary Hospitality Management 2023

Purpose Academic research on customer experience (CX) in the hospitality industry has recently experienced vast growth as managers have increasingly focused delivering distinctive experiences to their guests. Despite relevance of this topic, studies conducted area within hotel context are scarce and dispersed. This paper aims classify main academic present a definition CX, conceptual model, eme...

2006
Takuji Tanaka Hiroki Makita Masami Ohnishi Masaini Ohnishi Hideki Mori Kumiko Satoh Akira HarÃ

The chemopreventive effects of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) on oral Carcinogenesis induced by 4-nitroquinoline I-oxide (4-NQO) was investigated in male F344 rats. Rats were given 20 ppm of 4-NQO in their drinking water for 8 weeks to induce oral neo plasms or preneoplasms. Animals were fed diets containing 100 ppm AX or CX during the initiation or postinitiation pha...

2015
D. Ramesh M. Muniaraj P. Philip Samuel V. Thenmozhi A. Venkatesh J. Nagaraj B.K. Tyagi

BACKGROUND & OBJECTIVES Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia. The first major JE outbreak occurred in 1978 and since 1981 several outbreaks had been reported in the Cuddalore district (erstwhile South Arcot), Tamil Nadu, India. Entomological monitoring was carried out during January 2010 - March 2013, to determine the seasonal abundance and transmission ...

Journal: :Cancer research 2010
Adam Siddiqui-Jain Denis Drygin Nicole Streiner Peter Chua Fabrice Pierre Sean E O'Brien Josh Bliesath Mayuko Omori Nanni Huser Caroline Ho Chris Proffitt Michael K Schwaebe David M Ryckman William G Rice Kenna Anderes

Malignant transformation and maintenance of the malignant phenotype depends on oncogenic and non-oncogenic proteins that are essential to mediate oncogene signaling and to support the altered physiologic demands induced by transformation. Protein kinase CK2 supports key prosurvival signaling pathways and represents a prototypical non-oncogene. In this study, we describe CX-4945, a potent and se...

2016
Ji Hye Baek Kyungsook Kim Soon Sim Yang Seung Hun Park Bo Ram Song Hee-Woong Yun Sung In Jeong Young Jick Kim Byoung Hyun Min Moon Suk Kim

In this study, we examined whether porcine articular cartilage (PAC) is a suitable and effective anti-adhesive material. PAC, which contained no non-collagenous tissue components, was collected by mechanical manipulation and decellularization of porcine knee cartilage. The PAC film for use as an anti-adhesive barrier was easily shaped into various sizes using homemade silicone molds. The PAC fi...

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