Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A flexible loop structure comprising loop A (res. 189-209) and loop B (res. 577-608) at the domain interface is implicated in substrate entry to the active site. Here we determined kinetic and structural properties of POP with mutations in loop A, loop B, and in two additional flexible loops (the catalytic His l...

Evidence from cell studies indicates that persistent organic pollutants (POP) can induce insulin resistance, an essential component of the metabolic syndrome (MetS). We hypothesized that residential proximity to environmental sources of POP would be associated with the MetS in the population. The present study examined the association between residency in a zip code containing or abutting envir...

Pelvic organ prolapse (POP) is a common multifactorial condition. Matrix metalloproteinases (MMPs) are enzymes capable of breaking down various connective tissue elements. Single-nucleotide polymorphisms (SNPs) in regulatory areas of MMP-encoding genes can alter their transcription rate, and therefore the possible effect on pelvic floor supporting structures. The insertion of an adenine (A) bas...

The N2-posterior-contralateral (N2pc) component is an index in the domain of event-related potentials for exploring the underlying mechanism of visual-spatial attention. It has been disputed whether the attentional selection reflected by N2pc is primarily due to distracter suppression or target enhancement processes. We addressed this controversy by combining the pop-out item and the target fea...

This study aimed to investigate the relationship between bladder trabeculation, urinary function, and the stage of pelvic organ prolapse (POP). The medical records of 104 patients with POP who underwent cystoscopies and urodynamic studies were reviewed retrospectively. Age, incidence of detrusor instability, stage and site of POP, and the parameters of urodynamic studies of patients with and wi...

Percutaneous osteoplasty (POP) as a technical extension of percutaneous vertebroplasty (PVP) has been used to treat malignant disease that affects the skeletal system. POP has demonstrated good outcome for pain relief and functional improvement. Few studies have reported on the efficiency of POP to treat malignancies located in the femoral head. We designed a pilot study with the use of POP to ...

KEY CLINICAL MESSAGE Pelvic organ prolapse (POP) is common among multiparous elderly women. POP related to obstructive anuria is very uncommon, but can be life-threatening if untreated. In this report, the patient survived from a septic shock with multidisciplinary treatment and was completely cured of POP after tension-free vaginal mesh repair.

Motivated by the pop-stack-sorting map on symmetric groups, Defant defined an operator $\mathsf{Pop}_M : M \to M$ for each complete meet-semilattice $M$ $$\mathsf{Pop}_M(x)=\bigwedge(\{y\in M: y\lessdot x\}\cup \{x\}).$$ This paper concerns dynamics of $\mathsf{Pop}_{\mathrm{Tam}_n}$, where $\mathrm{Tam}_n$ is $n$-th Tamari lattice. We say element $x\in \mathrm{Tam}_n$ $t$-$\mathsf{Pop}$-sortab...

With the first metal enrichment by Population III (Pop III) supernovae (SNe), the formation of the first metal-enriched, Pop II stars becomes possible. In turn, Pop III star formation and early metal enrichment are slowed by the high-energy radiation emitted by Pop II stars. Thus, through the SNe and radiation they produce, Pops II and III co-evolve in the early Universe, one regulated by the o...

Introduction. Manufactured Colas are consumed universally as soft drinks. Evidence about the acid contents of Cola-beverages and its effects on teeth is rare. Aim. To assess (i) cola acidity and buffering capacity in vitro, (ii) tooth erosion after swishing with colas in vivo (iii) scanning electron microscopic effects on teeth of colas, and tooth-brush abrasion, and (iv) report a clinical case...