BACKGROUND-Chronic heart failure (CHF) impairs the endothelium-dependent, flow-mediated dilation (FMD) of small arteries. However, whether chronic angiotensin-converting enzyme (ACE) inhibition affects the impairment of FMD in CHF is unknown. We investigated the effects of long-term ACE inhibition on the FMD of peripheral arteries in rats with CHF and the mechanism(s) involved. METHODS AND RESU...

Previous mathematical models of spatial farm-to-farm transmission of foot and mouth disease (FMD) have explored the impacts of control measures such as culling and vaccination during a single outbreak in a country normally free of FMD. As a result, these models do not include factors that are relevant to countries where FMD is endemic in some regions, like long-term waning natural and vaccine i...

Unlike animals which are carriers of foot and mouth disease (FMD), sub-clinically infected animals may be highly contagious. The implications of sub-clinical infections for the control of FMD are serious because such animals are likely to disseminate the disease when in contact with susceptible livestock. Recent dissemination of FMD virus (FMDV) in Europe shows that sub-clinically infected anim...

The presence of FMD in many parts of the world implicates that veterinary authorities and stakeholders in Europe always will have to accept the risk of incursions of FMD. Although vaccination by itself does not produce carriers, vaccinated ruminants when exposed to FMD virus some can become carriers (vaccinated carriers). When discussing vaccination policies as a means of controlling FMD outbre...

Flow-mediated dilation (FMD) is strongly dependent on arterial size, but the reasons for this phenomenon are poorly understood. We have previously shown that FMD is greater in small brachial arteries because the shear stress stimulus is greater in small brachial arteries. However, it is unclear why the shear stimulus is greater in small arteries. Furthermore, this relationship has not been inve...

BACKGROUND Endothelial function is a prognostic predictor in patients undergoing percutaneous coronary intervention (PCI). However, in an era with widespread use of drug-eluting stents, the clinical relevance of endothelial dysfunction on restenosis in patients undergoing PCI has not been fully evaluated. METHODS This study included 80 patients with stable angina pectoris. Flow-mediated dilat...

The limb-specific effects of aging upon vessel structure and function are not well understood. Consequently, in 12 young (26 +/- 2 yr) and 12 old (72 +/- 1 yr) healthy subjects, we utilized ultrasound Doppler to evaluate intima-media thickness (IMT), ischemic reperfusion, and flow-mediated dilation (FMD) following (5 min) suprasystolic cuff occlusion in both the arm [brachial artery (BA)] and t...

CONTEXT Conduit artery flow-mediated dilation (FMD) is a noninvasive index of preclinical atherosclerosis in humans. Exercise interventions can improve FMD in both healthy and clinical populations. OBJECTIVE This systematic review and meta-analysis aimed to summarize the effect of exercise training on FMD in overweight and obese children and adolescents as well as investigate the role of card...

BACKGROUND Flow-mediated dilation (FMD) of human conduit arteries is, in part, related to shear stress-induced release of endothelium-derived nitric oxide (NO). However, NO synthase inhibitors do not completely abolish this FMD-response. Recently, a cytochrome P450 (CYP) epoxygenase of the 2C family was linked to NO- and prostacyclin-independent relaxation of conduit arteries. We therefore eval...

Abstract Introduction Fibromuscular dysplasia (FMD) is a rare, non-atherosclerotic, non-inflammatory vascular disorder that primarily affects renal and cerebrovascular vessels. Limited data are available on the clinical characteristics of FMD, particularly from UK/Europe. Methods We performed retrospective cohort analysis all cases carotid/cerebrovascular FMD presenting to our regional service,...