THE PREVALENCE of a number of elec-trocardiographic findings among the adult population of a total natural community was reported in an earlier article.' This community , Tecumseh, Michigan, is the site of a long-term study of a great variety of factors which may influence the health of the population. The first series of complete examinations of the participants was carried out in 1959 and 196...

Let Pn,r(x) be the generalized weighted means: Pn,r(x) = ( ∑n i=1 qix r i ) 1/r , where Pn,0(x) denotes the limit of Pn,r(x) as r → 0+, x = (x1,x2, . . . ,xn) and qi > 0 (1 ≤ i ≤ n) are positive real numbers with ∑n i=1 qi = 1. In this paper, we let q = minqi and always assume n≥ 2, 0 ≤ x1 < x2 < ··· < xn. We defineAn(x) = Pn,1(x),Gn(x) = Pn,0(x),Hn(x) = Pn,−1(x), and we will write Pn,r for Pn,...

Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1-/-) were found to develop epileptic activity in vivo and in vitro. Theta burst-induced long-term potentiation (LTP) and NMDA receptor...

Let K be a field of characteristic p > 0. It is proved that each automorphism σ ∈ AutK(D(Pn)) of the ring D(Pn) of differential operators on a polynomial algebra Pn = K[x1, . . . , xn] is uniquely determined by the elements σ(x1), . . . , σ(xn), and the set Frob(D(Pn)) of all the extensions of the Frobenius from certain maximal commutative polynomial subalgebras of D(Pn), like Pn, is equal to A...

The serine protease thrombin plays a role in signalling ischemic neuronal death in the brain. Paradoxically, endogenous neuroprotective mechanisms can be triggered by preconditioning with thrombin (thrombin preconditioning, TPC), leading to tolerance to cerebral ischemia. Here we studied the role of thrombin's endogenous potent inhibitor, protease nexin-1 (PN-1), in ischemia and in tolerance to...

Let pn denote the number of self-avoiding polygons of length n on a regular three-dimensional lattice, and let pn(K) be the number which have knot type K. The probability that a random polygon of length n has knot type K is pn(K)/pn and is known to decay exponentially with length [1, 2]. Little is known rigorously about the asymptotics of pn(K), but there is substantial numerical evidence [3, 4...

• Example: sort the projects P in some order p1 . . . pn. • Either pn is part of some optimal solution to P , or it isn’t. Let Π∗ be this (unknown) optimal solution. • Π∗ consists of the result of our first choice (i.e., either pn or nothing), combined with some subset Π′ of the remaining projects. • If pn is part Π∗, then Π′ must consist only of projects in P that do not conflict with P ; that...

four new complexes of the type [lco ((do)(doh) pn) cl] pf , where (do) (doh) pn = n , n &apos;- propanediylbis (2, 3-butanedione2-imine3-oxirne)a nd l =morpholine (mrpln) (i), benzylamine (bzlan) (ii), piperidine (pprdn)(iii) and pyrrolidine (prldn) (iv) have been synthesized and characterized by elemental analyses and spectroscopic methods. approximate values of the angular-overlap parameter, ...

The accumulation of hepatic TG and development of hepatic steatosis (HS) is a serious complication of the use of parenteral nutrition (PN) formulas containing a high percentage of dextrose. But whether fat emulsions or other nutrients can ameliorate the induction of HS by high-carbohydrate diets is still uncertain. We hypothesized that administration of a lipid emulsion (LE; Intralipid) and/or ...