Panax ginseng has been reported to exhibit a wide range of pharmacological and physiological actions. A method of heat-processing to enhance the efficacy of ginseng is well established in South Korea based on a long history of ethnopharmacological evidence. We investigated the increase in free radical-scavenging activity of Panax ginseng as a result of heat-processing and its active compounds r...

In our study (Sun et al., 2006), we conclude that FSH has a direct role in causing bone loss in hypogonadal mice. Our study does not, however, imply that estrogen and testosterone are not critical regulators of bone mass. To the contrary, we assert that sex steroids regulate bone formation and bone resorption, whereas FSH directly stimulates bone resorption. Problems in interpretation can arise...

These proceedings are based on a symposium that were presented at the European Society of Ophthalmology 2015 Congress in Vienna, Austria on 8 June 2015. The symposium was arranged to bring together leaders in ophthalmology to explore advances in the medical treatment of glaucoma. Many patients with glaucoma require combination therapy. Fixed-dose combinations represent a significant improvement...

A one-step, large-scale preparation of alkyne-containing hyper-branched polyglycerols (HPG) is reported. The HPGs undergo click reactions to organic azides allowing a range of applications.

The hypothalamus-pituitary-gonadal (HPG) axis plays a central role in the maintenance of homeostasis and disruptions in its function can have important implications for reproduction and other critical biological processes. A number of compounds found in aquatic environments are known to affect the HPG axis. In the present study, we used two-dimensional electrophoresis to investigate the proteom...

DeFries, Christa, "Regulation of levels and localization of thimet oligopeptidase in prostate cancer cells by β-estradiol" (2013). Honors Thesis Collection. Paper 161. Abstract The enzyme thimet oligopeptidease (TOP) catalyzes the hydrolysis of gonadotropin-releasing hormone (GnRH) in vitro, and evidence suggests that TOP is the primary enzyme responsible for GnRH hydrolysis in vivo, as well. I...

Hyperbranched polyglycerol (HPG) is modified with dodecanethiol (DS) via the "thiol-ene" click reaction to obtain an amphiphilic product DSHPG. The molecular structures of DSHPG samples are characterized by NMR, FTIR, and GPC, and the thermal behaviors are characterized by DSC and TGA. Gold nanoparticles (Au NPs) are prepared with DSHPG as the stabilizer and surface-modification reagent. The si...

Understanding sources of individual differences in steroid hormone production has important implications for the evolution of reproductive and social behaviors. In females in particular, little is known about the mechanistic sources of these individual differences, despite established linkages between sex steroids and a variety of fitness-related traits. Using captive female dark-eyed juncos (J...

Disorders of reproduction represent a significant social, medical, and economic burden for individuals and society. Approximately 1 in 10 couples in the United States are infertile, and each partner is equally likely to be affected (1). Although many causes of infertility can now be determined in both men and women, most couples still receive a diagnosis of idiopathic infertility. A subset of t...