Ethambutol (EMB), the first line drug in the treatment of tuberculosis, is an inhibitor of the biosynthesis of the cell wall compound - arabinogalactan. It was found that EMB at sub-inhibitory concentration increases the permeability of the M. vaccae cell wall, which was monitored by cell sensitization to erythromycin and rifampicin. The high permeability of the cell wall to hydrophobic compoun...

The mycobacterial cells were treated with 0.96 mg/ml of Ethambutol (EMB) and 0.64 mg/ml of Rifampicin (RIF) in Luria Bertani (LB) broth. The native and treated cells were serially diluted (10 to 10), from the 10 dilution native cells and antibiotics treated cells were imaged using Atomic Force Microscopy (AFM). The normal surface roughness (Rrms) of the native cells was 0.353 nm, whereas the su...

Marine Heatwaves (MHWs) are considered one of the main consequences global warming. MHWs negatively affect ecosystems, threaten economies, and intensify storms. In this work, we investigated characteristics in Mediterranean Sea from 1982 to 2020 examined relationship between their frequency teleconnection patterns (e.g., East Atlantic Pattern (EAP) Atlantic/Western Russian (EATL/WRUS)). We then...

BACKGROUND Assessment of gene expression in peripheral blood may provide a noninvasive screening test for allograft rejection. We hypothesized that changes in peripheral blood expression profiles would correlate with biopsy-proven rejection and would resolve after treatment of rejection episodes. METHODS AND RESULTS We performed a case-control study nested within a cohort of 189 cardiac trans...

BACKGROUND The emergence of drug resistance is one of the most important threats to tuberculosis control programs. This study was aimed to analyze the frequency of gene mutations associated with resistance to isoniazid (INH), rifampicin (RMP) and ethambutol (EMB) among Mycobacterium tuberculosis isolates from Northwest Ethiopia, and to assess the performance of the GenoType® MTBDRplus and GenoT...

OBJECTIVES We sought to evaluate the diagnostic performance of cardiovascular magnetic resonance imaging (CMRI) for detection of cardiac amyloidosis compared with endomyocardial biopsy (EMB) in a clinical routine setting. BACKGROUND For the clinical workup of heart failure with restrictive filling, pattern cardiac amyloidosis is an important differential diagnosis that is difficult to verify ...

BACKGROUND The emergence of resistant tuberculosis (TB) is a major setback to the global control of the disease as the treatment of such resistance is complex and expensive. Use of direct detection of mutations by molecular methods could facilitate rapid diagnosis of resistance to offset diagnostic delays. We evaluated the performance of the Genotype MTBDRsl (Hain Life Sciences) for the detecti...

BACKGROUND Based on a plenty of different applications, intracardiac echocardiography (ICE) is now a well-established technology in complex electrophysiological procedures. Recently, ICE has become the most widely used ultrasound-based imaging tool to guide diagnostic endomyocardial biopsy (EMB). EMB of cardiac mass guided by ICE is an interesting application of ICE. Allowing a correct position...