OBJECTIVE To estimate survival, the number of life-years gained and cost effectiveness of antiretroviral therapy (ART) regimens, denoted as ERA-I [zidovudine + (didanosine or zalcitabine)]; ERA-II [stavudine + (didanosine or zalcitabine) or lamivudine + (zidovudine or didanosine or zalcitabine or stavudine)]; and ERA-III [2 nucleoside reverse transcriptase inhibitors + (1 protease inhibitor or ...

Increasingly stringent regulations for drinking water quality have stimulated the application of ultrafiltration to water treatment. In addition to removing particulate materials from water (including microorganisms, bacteria and viruses), the use of membrane treatment also meets purification requirements. However, irreversible fouling curtails the economic viability of such a process. Experime...

The study of the Mediterranean cyclones from a climatological point of view has been one of the objectives of the first phase of WMO WWRP MEDEX (MEDiterranean EXperiment) project. It has been revealing itself like a good procedure for extracting conclusions about their characteristics and behaviour. The implementation on ECMWF ERA40 reanalysis of the method for detecting and tracking the cyclon...

The age of stratospheric air is computed with a trajectory model, using ECMWF ERA-40 3-D-Var and operational 4-D-Var winds. The sensitivity to the forecast period and assimilation technique are studied, and the results are compared with observations and with results from a chemistry transport model that uses the same data sets. A large 5 number of backward trajectories is started in the stratos...

social changes and considering people’s needs are seen as the most important issues in the changes of persian poetry in constitutional era. the writers of this article have considered the views of western and iranian critics to study the function of the addressee in the changes of persian poetry in constitutional era. the use of such a study is that the writers have found and analyzed many soci...

Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-a (ERa). Phosphorylation of both ERa and AIB1 has been shown to have profound effects on their functions. In addition, proteasome-mediated degradation plays a major role by regulating their stability and activity. CK1d, a member of the ubiqui...

Breast cancers with estrogen receptor a (ERa) expression are often more differentiated histologically than ERa-negative tumors, but the reasons for this difference are poorly understood. One possible explanation is that transcriptional cofactors associated with ERa determine the expression of genes which promote a more differentiated phenotype. In this study, we identify one such cofactor as co...

The contents of ascorbic acid (AsA) and erythrobic acid (ErA) in the tissues of guinea pigs intraperitoneally injected with AsA and/or ErA were determined to learn the difference in their retention in the tissues. After 10 d of AsA depletion, the guinea pigs were intraperitoneally injected with 5 mg of AsA, or 5 mg of ErA, or 5 mg of each. At day 5 of repletion, the guinea pigs were killed and ...