The transfer of agronomically useful genes from wild wheat species into cultivated wheat is one of the most effective approaches to improvement of wheat varieties. To evaluate the transfer of genes from Dasypyrum villosum into Triticum aestivum, wheat quality and disease resistance was evaluated in two new translocation lines, T1DL•1V#3S and T1DS•1V#3L. We examined the levels of stripe rust res...

In a paper published in the International Journal of Geriatric Psychiatry (Sanchez-Arenas et al. 2014), Sanchez-Arenas et al. concern themselves with the reliability of the EQ-5D-3L, which they refer to solely as the EQ-5D. They investigate both the reliability of the five single dimensions and the reliability of the whole instrument. Sanchez-Arenas et al. report that they have determined the r...

Much remains to be discovered about the etiology of heart valve disease and the molecular level mechanisms that drive it. The MAPK/ERK pathway influences calcification in many cell types and has been linked to the expression of a contractile phenotype in valvular interstitial cells (VICs). However, a direct correlation between MAPK/ERK pathway activity and VIC calcification has not been previou...

Department of Pharmacy Practice, Faculty of Pharmacy, Monash University, Melbourne, VIC. Johnson George, MPharm, PhD Scholar; David C M Kong, MPharm PhD, Lecturer; and Senior Pharmacist, The Alfred, Melbourne, VIC; Kay Stewart, BPharm(Hons), PhD, Senior Lecturer. Ambulatory and Community Services, The Alfred, Melbourne, VIC. Lisa L Ioannides-Demos, BPharm, PhD, Senior Research Scientist; and Re...

This paper addresses the effectiveness of auctions and legal unbundling as regulatory measures to tender a vertically integrated industry more competitive. Specifically, I analyze if implementing auctions and legal unbundling can counter market power in an industry where a Vertically Integrated Corporation (VIC) has a monopoly position in an essential, scarce upstream activity and also owns one...

BACKGROUND The Quality-Adjusted Life Year (QALY) is a measure that combines life extension and health improvement in a single score, reflecting preferences around different types of health gain. It can therefore be used to inform decision-making around allocation of health care resources to mutually exclusive options that would produce qualitatively different health benefits. A number of qualit...

BACKGROUND AND OBJECTIVE Huntington's disease (HD) is an inherited neurodegenerative disorder that heavily affects the patient's motor, cognitive, and psychological functions. Yet, very few studies have measured the impact of this disease on the patient's health-related quality of life (HRQoL) with specific and validated instruments. The aim of this study was to explore the impact of HD on the ...

Objective: To estimate an interim five-level EuroQol five-dimensional (EQ-5D-5L) value set for Poland on the basis of the crosswalk methodology developed by the EuroQol Group. Methods: On the basis of data from 3691 respondents from six European countries, the EuroQol Group has developed a method of obtaining interim value sets for the EQ-5D-5L by means of mapping to the available three-level E...

Isocitrate lyase (ICL, types 1 and 2) is the first enzyme of the glyoxylate shunt, an essential pathway for Mycobacterium tuberculosis (Mtb) during the persistent phase of human TB infection. Here, we report 2-vinyl-d-isocitrate (2-VIC) as a mechanism-based inactivator of Mtb ICL1 and ICL2. The enzyme-catalyzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-vinylglyoxylate, which ...

For a low-power wireless communication, a fast-Fourier-transform (FFT) LSI for an orthogonal frequency division multiplexing (OFDM) system has been implemented with current-mode circuits. In this current-mode OFDM system, a voltage-current converter (VIC) should be designed with an operating frequency of more than 40 MHz, because the frequency bandwidth of the OFDM signal is recommended as 20 M...