Cyclic ADP ribose (cADPR) is a novel second messenger that releases calcium from intracellular calcium stores, but works independently of inositol 1,4,5-trisphosphate. In mammals ADP-ribosyl cyclase function is found in two membrane proteins, CD38 and bone marrow stromal cell antigen 1 (BST-1)/CD157. These enzymes are exposed extracellularly and also possess cADPR hydrolase activity, but an int...

We introduce a new Priestley-style topological duality for N4-lattices, which are the algebraic counterpart of paraconsistent Nelson logic. Our duality differs from the existing one, due to S. Odintsov, in that we only rely on Esakia duality for Heyting algebras and not on the duality for De Morgan algebras of Cornish and Fowler. A major advantage of our approach is that we obtain a simple desc...

Extracellular RNase N4 from Neurospora crassa is derepressible by limitation of any of the three nutrient elements obtainable from RNA. We have purified and characterized the enzyme from cultures grown under each of the three states of derepression. The purification procedure consisted of an ultrafiltration step, cation-exchange chromatography, and gel filtration. We found only one enzyme (N4) ...

We have studied the mutagenic properties of ribonucleotide analogues by reverse transcription to understand their potential as antiretroviral agents by mutagenesis of the viral genome. The templating properties of nucleotide analogues including 6-(beta-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c](1,2)oxazin-7-one, N4-hydroxycytidine, N4-methoxycytidine, N4-methylcytidine and 4-semicarbazidoc...

Analogs of the antimitotic herbicide oryzalin (3,5-dinitro-N4,N4-di-n-propylsulfanilamide) were recently prepared that were more potent in vitro than the parent compound against the kinetoplastid parasite Leishmania donovani (Bioorg Med Chem Lett 12:2395-2398, 2002). In the present work, we show that the most active molecule in the group, N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB...

The structure and transport properties of the pure salt [N4]BF4 this located in contact with (110) surface a-Al2O3 were studied using a MD computer simulation order to reveal effect salt/oxide interface on salt. radial distribution functions ions their mean square displacements analyzed as function temperature during cooling It was found that all cases anions are more mobile than cations. molte...

Legume/maize intercropping has been practiced in many countries as a sustainable cropping system, but the effects of legumes with maize together N application rates on biomass yield, quality, water-use efficiency (WUE), and nitrogen use (NUE) are limited under arid conditions Northwest China. Field experiments were carried out areas China from 2019 to 2020 three planting patterns (LM: Dolichos ...