The folate receptor (FR) type alpha is known to be frequently overexpressed in ovarian cancer and is the target for a number of novel experimental cancer therapies. The relative levels of FR expression among specific cell types and its relationship to malignant transformation have not been adequately established because of several inherent limitations of the immunocytochemical approaches used p...

BACKGROUND AND AIMS Left double-lumen endobronchial tube (DLT) sizes are selected using tracheal diameters and left mainstem bronchial diameters (LMBDs) determined from chest radiographs or computed tomography (CT) scans. In Western women, 35-Fr or 37-Fr DLTs are often selected. However, difficulties can be encountered when inserting 32-Fr or 35-Fr DLTs in Japanese women. We investigated succes...

BACKGROUND The influence of size on the effectiveness of nasobiliary catheters has not yet been studied. We compared biliary drainage effectiveness and procedure-related discomfort and adverse events in 5 French (Fr) and 7 Fr nasobiliary catheters. METHODS We prospectively studied 100 patients undergoing endoscopic biliary drainage for obstructive jaundice, who were randomly allocated to a 5 ...

Given a power q of a prime number p and “nice” polynomials f1, . . . , fr ∈ Fq[T, X] with r = 1 if p = 2, we establish an asymptotic formula for the number of pairs (a1, a2) ∈ Fq such that f1(T, a1T + a2), . . . , fr(T, a1T + a2) are irreducible in Fq[T ]. In particular that number tends to infinity with q. MR Classification: 12E30 Directory: \Jarden\Diary\BSJ 23 December, 2011 * Alexander von ...

OBJECTIVES There is compelling evidence that pathological high-frequency oscillations (HFOs), called fast ripples (FR, 150-500Hz), reflect abnormal synchronous neuronal discharges in areas responsible for seizure genesis in patients with mesial temporal lobe epilepsy (MTLE). It is hypothesized that morphological changes associated with hippocampal atrophy (HA) contribute to the generation of FR...

Two nuclear genes, Fr and Fr2, have been identified that restore pollen fertility to cytoplasmic male sterile (CMS) common bean (Phaseolus vulgaris L.) by apparently distinct mechanisms. Whereas Fr2 appears to suppress the expression of a male sterility associated mitochondrial sequence (designated pvs), Fr restores pollen fertility by causing the elimination of this unusual mitochondrial DNA-s...

Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.

Alain Cardon President of the jury University of Paris VI (FR) Pascal Bouvry Supervisor University of Luxembourg (LU) Frédéric Guinand Supervisor University of Le Havre (FR) Serge Chaumette Reviewer University of Bordeaux (FR) Marco conti Reviewer CNR, Pisa (IT) Steffen Rothkugel Member University of Luxembourg (LU) Enrique Alba Member University of Málaga (ES) Michel Syska Member INRIA/Univers...