The prediction of a protein's tertiary structure, given its amino acid sequence, is one of the intriguing problems in biophysics and computational biology. Anfinsen's thermodynamic hypothesis indicates that the tertiary structure of a protein is the minimum free-energy conformation 1. Based on Anfinsen's hypothesis, the protein structure predict-tion problem can be treated as a global optimizat...

Inflammatory breast cancer (IBC) is rare, but it is the most aggressive subtype of breast cancer. IBC has a unique presentation of diffuse tumor cell clusters called tumor emboli in the dermis of the chest wall that block lymph vessels causing a painful, erythematous, and edematous breast. Lack of effective therapeutic treatments has caused mortality rates of this cancer to reach 20%-30% in cas...

Graphene aerogel materials have attracted increasing attention owing to their large specific surface area, high conductivity and electronic interactions. Here, we report for the first time a novel strategy for the synthesis of nitrogen-doped activated graphene aerogel/gold nanoparticles (N-doped AGA/GNs). First, the mixture of graphite oxide, 2,4,6-trihydroxybenzaldehyde, urea and potassium hyd...

BACKGROUND Mucopolysaccharidosis type IIID (MPS-IIID), or Sanfilippo syndrome type D, is a rare autosomal recessive lysosomal storage disorder caused by mutations in the N-acetylglucosamine-6-sulfatase (GNS) gene, leading to impaired degradation of heparan sulfate. OBJECTIVES To report the natural history of MPS-IIID in 2 siblings described by Kaplan and Wolfe in 1987 and to study the phenoty...

This study was carried out at Federal Polytechnic; Ado Ekiti in state on geochemical appraisal of three different genetically derived lateritic soils from south western Nigeria and their respective engineering performance 2019. Twelve (12) disturbed soil samples were collected granite (GDS), gneiss (GNS) migmatite (MGS) rock terrains. These four horizons 0.5m intervals, resulting into a maximum...

to study the tolerance of genotypes under terminal drought stress, 20 promising winter and facultative bread wheat genotypes were evaluated at karadj, ardebil, arak and hamedan agricultural research stations during 2001-02 cropping season. the experimental design in all the locations was randomized complete block of three replications. grain yield (yld), harvest index (hi), grain number per spi...

INTRODUCTION A 13-year-old child was clinically diagnosed with mucopolysaccharidosis type VI-Maroteaux-Lamy syndrome (MPS VI) at the age of 5 years, and the diagnosis was confirmed biochemically and genetically (homozygous mutation in ARSB gene). At that time, his older brother manifested with increasing severe mental retardation. His urinary glycosaminoglycan excretion in urine was elevated, b...

Abstract We prove that the generator of $$L^2$$ L 2 implementation a KMS-symmetric quantum Markov semigroup can be expressed as square derivation with values in Hilbert bimodule, extending earlier results by Cipriani and Sauvageot for tracially symmetric semigroups seco...

Thepurpose of this studywas todetermine the capacity ofMK-1775, apotentWee-1 inhibitor, to abrogate the radiation-induced G2 checkpoint arrest andmodulate radiosensitivity in glioblastoma cell models and normal human astrocytes. The radiation-induced checkpoint response of established glioblastoma cell lines, glioblastoma neural stem (GNS) cells, and astrocytes were determined in vitro by flow ...