Abstract Background Usual interstitial pneumonia (UIP) is a fatal disease that associated with poor prognosis and survival. Several growth factors such as IGFs (insulin-like factors) IGFBPs factor binding proteins) seem to take part this pathogenesis. Pirfenidone an immunosuppressant drug thought have anti-inflammatory anti-fibrotic effects both in vitro vivo. Objective To assess IGFBP1 IGFBP2 ...