نتایج جستجو برای: ژن kiss1
تعداد نتایج: 16558 فیلتر نتایج به سال:
Kisspeptins are well known as mediators of the coordinated communication between the brain-pituitary axis and the gonads in many vertebrates. To test the hypothesis that gonadal steroids regulate kiss1 and kiss2 mRNA expression in European sea bass (a teleost fish), we examined the brains of gonad-intact (control) and castrated animals, as well as castrated males (GDX) and ovariectomized female...
Several studies have shown that neuropeptide Y (NPY) is considered to be one of the key regulators of the hypothalamic-pituitary-gonadal axis in the mammals. Also, kisspeptin is a powerful upstream regulator of gonadotropin-releasing hormone neurons in the hypothalamus. The present study aims to investigate the effects of the intracerebroventricular (ICV) injection of NPY and BIBP3226 (NPY rece...
مقدمه: مسیرهای عصبی داخل هیپوتالاموسی نوروپپتید y (npy)، اپیوئیدها و کیسپپتین از مهمترین تنظیمکنندههای فعالیت تولیدمثلی هستند. مرفین بیان ژن npy و کیسپپتین (kiss1) را کاهش میدهد. در حالی که کیسپپتین یا نالوکسون اثرات تحریکی بر بیان ژن npy اعمال میکنند. در این تحقیق نقش مسیر کیسپپتین/gpr54 در میانجیگری اثرات مرفین بر بیان ژن npy در هیپوتالاموس موشهای صحرایی نر بررسی شد. روش ها: چهل و...
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two discrete kisspeptin neuronal populations, which are sexually dimorphic and are believed to make distinct contributions to reproductive physiology. Within these kisspeptin neuron populations, Kiss1 expression is direc...
Kisspeptin is the product of the KISS1 (KiSS-1 metastasissuppressor) gene and is the ligand for the G-protein– coupled receptor, now known as the KISS1 receptor (KISS1R) (1 ). Both kisspeptin and KISS1R play a crucial role in the regulation of reproduction and puberty (1 ). The KISS1 gene encodes a precursor peptide of 145 amino acid residues, which undergoes proteolytic processing to generate ...
Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
OBJECTIVE Puberty is a key developmental phenomenon highly sensitive to metabolic modulation. Worrying trends of changes in the timing of puberty have been reported in humans. These might be linked to the escalating prevalence of childhood obesity and could have deleterious impacts on later (cardio-metabolic) health, but their underlying mechanisms remain unsolved. The neuropeptide α-MSH, made ...
BACKGROUND/AIMS Hypothalamic hamartomas are the most common identifiable cause of central precocious puberty (CPP). Hamartoma characteristics proposed to be associated with CPP include specific anatomic features and expression of molecules such as gonadotropin-releasing hormone (GnRH), transforming growth factor alpha (TGFalpha), and GRM1A, which encodes the type 1 metabotropic glutamate recept...
AIMS KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple ...
The European eel (Anguilla anguilla) presents a blockade of sexual maturation at a prepubertal stage due to a deficient production of gonadotropins. We previously initiated, in the eel, the investigation of the kisspeptin system, one of the major gatekeepers of puberty in mammals, and we predicted the sequence of two Kiss genes. In the present study, we cloned and sequenced Kiss1 and Kiss2 cDNA...
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